The direct regulation

The dissertation aims to clarify the theoretical and practical issues on the Government’s responsibility to the NA. It also proposes viewpoints and solutions to further improve functions and duties of the two agencies, and ensuring direct and indirect regulations on the Government’s responsibility to the NA are enforced in practice.

27p angicungduoc12 08-06-2021 20 5   Download

The objective of the study was to find the explant resources, the type and concentration of plant growth regulators (PGRs), as well as the in vitro culture conditions suitable for different morphogenesis processes - callus induction, direct embryogenesis, shoot and root formation, etc. The growth and development of in vitro Ngoc Linh ginseng derived from thin cell layer (TCL) was examined in Quang Nam to assess the adaptability of in vitro Ngoc Linh plantlets in its natural territory, compared to those growing in Bidoup - Nui Ba National Park, Lam Dong.

27p capheviahe27 23-02-2021 21 5   Download

India has witnessed significant growth in the manufacture of automobiles. Growth in vehicle population results in several environmental issues. Regulators have been controlling the emissions by setting standards.

6p lucastanguyen 01-06-2020 30 3   Download

The research objectives of the thesis are to identify the characteristics of the enterprise; the situation of internal control in enterprises; determine the relationship between internal control and performance and regulatory compliance in enterprises; propose solutions to improve internal control to help businesses achieve operational efficiency and comply with regulations.

0p dungmaithuy 17-09-2019 23 3   Download

The objective of the study was to find the explant resources, the type and concentration of plant growth regulators (PGRs), as well as the in vitro culture conditions suitable for different morphogenesis processes - callus induction, direct embryogenesis, shoot and root formation, etc. The growth and development of in vitro Ngoc Linh ginseng derived from thin cell layer (TCL) was examined in Quang Nam to assess the adaptability of in vitro Ngoc Linh plantlets in its natural territory, compared to those growing in Bidoup - Nui Ba National Park, Lam Dong.

27p xacxuoc4321 09-07-2019 33 5   Download

Trong một số các tài liệu, danh từ hệ thống (system) được định nghĩa là tập hợp hay sắp xếp kết nối có trật tự các phần tử vật lý theo một thể.Danh từ điều khiển (control) thường mang ý nghĩa là điều chỉnh (regulate), hướng đến nhắm đến (direct) và thực thi tác vụ hay một lệnh (command).

13p esc_12 03-08-2013 61 15   Download

SHP-1, a protein-tyrosine phosphatase with two srchomology 2 domains, is expressed predominantly in hematopoietic and epithelial cells and has been implicated in numerous signaling pathways as a negative regulator. Two promoters direct the expression of human and murine SHP-1, and two types of transcripts (I) and (II) SHP-1, are initiated from each of these promoters. The cDNA sequences of (I)SHP-1 and (II)SHP-1 are identical except in the 5¢ untranslated region and in the first few coding nucleotides.

8p system191 01-06-2013 36 3   Download

The p25rum1 is an inhibitor of Cdc2 kinase expressed in fission yeast and plays an important role in cell-cycle control. As its amino-acid sequence suggests that p25rum1 has putative phosphorylation sites for mitogen-activated protein kinase (MAPK), we investigated the ability of MAPK to phosphorylate p25rum1. Direct in vitro kinase assay using GST-fusion proteins of wild-type as well as various mutants of p25rum1 demonstrated that MAPK phosphorylates the N-terminal portion of p25rum1 and residues Thr13 and Ser19 are major phosphorylation sites for MAPK....

11p research12 01-06-2013 46 4   Download

There are at least three well-defined signalling cascades engaged directly in the physiological regulation of cardiac circulatory function: theb1-adrenoceptors that control the cardiac contractile apparatus,the renin-angiotensin-aldo-sterone system involved in regulating bloodpressure and the natriuretic peptides contributing at least to the factors determining circulating volume.

18p research12 29-04-2013 39 3   Download

The hepatocyte growth factor-regulated tyrosine kinase substrate Hrs is an early endosomal protein that is thought to play a regulatory role in the trafficking of growth factor/ receptor complexes through early endosomes. Stimulation of cells with epidermal growth factor (EGF) rapidly leads to phosphorylation of Hrs, raising the question whether the receptor tyrosine kinase phosphorylates Hrs directly. Here, we present evidence that a downstream kinase, rather than the active receptor kinase is responsible. ...

7p research12 23-04-2013 36 2   Download

Expression of DNase II in macrophages is potentially cru-cially important in the removal of unwantedDNA.We have previously shown that DNase II expression is up-regulated at the transcriptional level during the phorbol 12-myristate-13-acetate (PMA)-induced differentiation of HL-60 and THP-1 cells. In this study, we investigated thecis-regulatory elements and transcription factors involved in this process in HL-60 cells.

8p fptmusic 16-04-2013 47 3   Download

The peptide hormone endothelin transmits various signals throughGprotein-coupled receptors, the endothelin type A (ETAR) and B (ETBR) receptors. Caveolae are specialized lipid rafts containing polymerized caveolins. We examined the interaction of ETBR with caveolin-1, expressed in Sf9, COS-1, and HEK293 cells, and its effects on the subcellular distribution and the signal transduction of ETBR.

12p fptmusic 16-04-2013 27 2   Download

The innate antiviral response requires the induction of genes and proteins with activities that limit virus replication. Among these, the well-character-ized interferon b (IFNB) gene is regulated through the cooperation of AP-1, NF-jB and interferon regulatory factor 3 (IRF-3) transcription fac-tors. Using a constitutively active form of IRF-3, IRF-3 5D, we showed previously that IRF-3 also regulates an IFN-independent antiviral response through the direct induction of IFN-stimulated genes.

12p fptmusic 11-04-2013 31 3   Download

Ammonium assimilation inEscherichia coliis regulated through multiple mechanisms (metabolic, signal transduction leading to covalent modification, transcription, and translation), which (in-)directly affect the activities of its two ammonium-assimilating enzymes, i.e. glutamine synthetase (GS) and glutamate dehydrogenase (GDH).

21p awards 06-04-2013 29 4   Download

The Wnt pathway controls biological processes via the regulation of target gene expression. The expression of direct Wnt target genes, e.g.cyclin D1 and MYC, is activated by the transcription factor TCF, which binds to specific sequence motifs in the promoter. Indirect target genes are regulated via transcription regulators, which are targets of the Wnt pathway.

16p awards 06-04-2013 39 4   Download

Juvenile hormones (JHs) of insects are sesquiterpenoids that regulate a great diversity of processes in development and reproduction. As yet the molecular modes of action of JH are poorly understood. TheMethoprene-tolerant (Met) gene of Drosophila melanogasterhas been found to be responsible for resistance to a JH analogue (JHA) insecticide, methoprene. Previous studies onMethave implicated its involvement in JH signaling, although direct evidence is lacking.

0p awards 05-04-2013 33 1   Download

Anovel caspase-like activity, which is directly regulatedwith cell proliferation is a candidate to regulate the abundance of the cyclin-dependent kinase inhibitor, p27 KIP1 , in human lymphoid cells.This activity, whichwe termKIPase activity, can also cleave a subset of caspase substrates.Here we demonstrate thatKIPase is anovel enzymedistinct fromany of the previously characterized human caspases.

8p dell39 03-04-2013 39 3   Download

The HIVEP gene family encodes for very large sequence-specific DNAbinding proteins containing multiple zinc fingers. Three mammalian paralogous genes have been identified, HIVEP1,-2and -3, as well as the closely related Drosophilagene,Schnurri. These genes have been found to directly participate in the transcriptional regulation of a variety of genes. Mammalian HIVEP members have been implicated in signaling by TNF-aand in the positive selec-tion of thymocytes, whileSchnurrihas been shown to be an essential component of theTGF-bsignalingpathway. ...

10p dell39 03-04-2013 37 5   Download

We have investigated the direct effect of arachidonic acid on cholesterol transport in intact cells or isolated mitochondria from steroidogenic cells and the effect of cyclic-AMP on the specific release of this fatty acid inside the mitochondria. We show for the first time that cyclic-AMP can regulate the release of arachidonic acid in a specialized compartment of MA-10 Leydig cells, e.g.

11p inspiron33 23-03-2013 35 5   Download

2-Amino 3-carboxymuconate 6-semialdehyde decarboxylase (ACMSD, EC 4.1.1.45) plays a key role in tryptophan catabolism. By diverting 2-amino 3-carboxymuconate semialdehyde from quinolinate production, the enzyme regulates NAD biosynthesis from the amino acid, directly affecting quinoli-nate and picolinate formation.

14p galaxyss3 21-03-2013 47 3   Download