The first humans

Metformin is an oral antidiabetic drug from the biguanide class and it is the first-line drug chosen for the treatment of type 2 diabetes. This is a drug on the list of pharmaceutical substances required to report bioequivalence study data when registering the drug. To develop a capillary zone electrophoresis method for determining metformin hydrochloride in human plasma; To validate the method.

10p vifaye 20-09-2024 4 1   Download

The result pointed out that only 5 g of soft tissue from N. glans (equivalent to 2–3 specimens) containing maximum toxicity detected in the present study may cause human death if consumed. Fhe first time, this study identified TTXs in the gastropods as a causative toxin in the poisoning in Vietnam. Moreover, 65.5% of studied specimens with high toxicity higher than 100 MU/g, including 16.1%, showing extremely high toxicity (> 1,000 MU/g). The results suggested that this gastropod is quite dangerous for human consumption and should be alerted to public awareness.

6p dianmotminh02 03-05-2024 7 1   Download

In the scientific work has been modified the impact of the exploitation of natural resources (nonrenewable oil and gas reserves) on balanced economic development and been researched Karl Marx's production scheme. Marx's simple and extensive reproduction scheme based on supply chain management, rather I-capital sector was divided into 3 parts for physical, natural and human capitals, and at first, theoretically modified and analyzed added value from the exploitation of natural capital (oil and gas reserves).

6p longtimenosee10 26-04-2024 4 2   Download

This study contributes to the existing literature in several ways. First of all, this is the first study to explore the changes in disclosure practices driven by IFRS adoption in terms of HCE. Although some prior literature anticipates these changes, so far no study has provide the empirical evidence.

210p runthenight04 02-02-2023 12 3   Download

The work presented in this thesis illustrates strategies to improve the detection of glucose by NanoZymes. This was done by first determining the NanoZyme activity of Cu and bimetallic nanoparticles of Cu, followed by the application of this activity towards biosensing of glucose.

127p runthenight04 02-02-2023 4 2   Download

The aim of this research study "Exploring human resource management practices: an empirical study of the performing arts companies in Australia" is to explore HRM practices in the performing arts companies in Australia, using a qualitative research design and two phases of data collection. Firstly, interviews were conducted, with the overall objective to acquire richer data from key stakeholders on the perceived HRM practices in the performing arts sector, and the associated impact of the environment, for example, policy context and funding arrangements.

328p runthenight04 02-02-2023 12 3   Download

The objectives are as follows a compact presentation of human actions: Joints in the skeleton model play different roles in each action. The first objective is to find action representations that are efficient for action recognition.

130p caphesuadathemchanh 29-03-2022 18 6   Download

In parallel with these results, the diagrams of Gibbs et al. supported the same seawater intrusion phenomena. Brackish karst springs first roseand then fell below sea level with epirogenic movements during the geological period, and therefore, karstification progressed. The samples were oversaturated with calcite, dolomite, and quartz, whereas they were undersaturated with gypsum and halite. The Al, Cu, and Zn values of some of the water samples exceeded the tolerance limit of aquatic life standards.

21p tanmocphong 29-01-2022 10 1   Download

RNA polymerase II (Pol II) is a 12 subunit protein complex from yeast to human that is required for gene expression. Gdown1 containing Pol II [Pol II (G)] is a special form of Pol II that is catalytically inactive and heavily depends on the 30-subunit Mediator complex for its activator and basal dependent function in vitro. Here we report for the first time, the identification and the generation of a 15-subunit human Mediator complex via the novel multibac baculovirus expression system that is fully responsive to Pol II (G).

9p thiencuuchu 27-11-2021 21 3   Download

Hepatocellular carcinoma (HCC) is one of the deadliest cancers. Research on HCC so far primarily focused on genes and provided limited information on genomic repeats, which constitute more than half of the human genome and contribute to genomic stability. In line with this, repeat dysregulation was significantly shown to be pathological in various cancers and other diseases. In this study, we aimed to determine the full repeat expression profile of HCC for the first time.

14p thiencuuchu 27-11-2021 21 3   Download

Quantifying the multiple processes which control and modulate the extent of oral bioavailability for drug candidates is critical to accurate projection of human pharmacokinetics (PK). Understanding how gut wall metabolism and hepatic elimination factor into first-pass clearance of drugs has improved enormously. Typically, the cytochrome P450s, uridine 5′- diphosphate-glucuronosyltransferases and sulfotransferases, are the main enzyme classes responsible for drug metabolism. Knowledge of the isoforms functionally expressed within organs of first-pass clearance, their anatomical topology (e.

16p caothientrangnguyen 09-05-2020 18 0   Download

The scope of research examining the meaning and meaningfulness of work is rather broad; I therefore believe it is necessary to first provide an overview of research approaches before describing my own approach. Depending on the definition of the concept of the meaning of work they used, researchers took various approaches. According to one group of researchers, the meaning of work and the meaningfulness of work is necessarily a subjective matter, with the meaning of work defined intrinsically (coming from the individual) (e.g. Simon, 1997; Isaksen, 2000).

31p kethamoi2 14-12-2019 26 4   Download

The following sections outline and analyze the key differences between financial advisors and Robo-Advisors. First with a comparison of fees, the different advisors are compared, contrasted, and the implications of different fee structures analyzed. Second with comparisons of performance and an overview of the different financial instruments and strategies used by advisors. Third is an overview of the customization ability for both human and Robo-Advisors. Ending with a conclusion outlining the key points made throughout the thesis.

20p fugu897 03-07-2019 15 1   Download

This study explains the effects of repatriates on managers returning from foreign assignments. The first chapter provides the reader with an introduction to my chosen topic, the justification of undertaking the topic and my research objectives. The second chapter explains the research methodology, my questionnaire design and the problems I encountered when gathering information. The study goes on to explain the expatriation/repatriation process in detail. It begins with the selection criteria needed for expatriation and goes on to criticize it.

85p nguyenyenyn117 18-06-2019 29 6   Download

The first humanlike creatures appeared in Africa four million years ago. Early humans left no written records. Without such records, archaeologists and anthropologists have had to rely on fossils, artifacts, and skeletal remains to develop theories about their lives. Researchers have concluded that the earliest humans lived as hunters and gatherers and focused on basic needs. Only millions of years later did they develop the skills and tools necessary to engage in agriculture and to build the first civilizations.

87p tangtuy05 01-04-2016 71 10   Download

Typical of the grassland dwellers of the continent is the American antelope, or pronghorn. 2. Of the millions who saw Haley’s comet in 1986, how many people will live long enough to see it return in the twenty-first century. 3. Anthropologists have discovered that fear, happiness, sadness, and surprise are universally reflected in facial expressions. 4. Because of its irritating effect on humans, the use of phenol as a general antiseptic has been largely discontinued. 5.

9p thanhtung911 17-08-2013 164 23   Download

Register your name and address on the Web site in order to ------- a purchase online. (A) make (B) shop (C) owe (D) use 102. All ------- for time off must go through the Human Resources Department first. (A) request (B) requests (C) requested (D) requesting 103. Despite it being his first time in an authority position, Mark led the project remarkably -------. (A) partly (B) even (C) yet (D) well 104. The detailed analyses of third and fourth quarter sales are included in ------- final report. (A) he (B) his (C) him (D) himself...

10p logomay 12-06-2013 93 15   Download

A Brief History 1958: First integrated circuit – Flip-flop using two transistors – Built by Jack Kilby at Texas Instruments  2010 – Intel Core i7 µprocessor • 2.3 billion transistors – 64 Gb Flash memory • 16 billion transistors 53% compound annual growth rate over 50 years – No other technology has grown so fast so long  Driven by miniaturization of transistors – Smaller is cheaper, faster, lower in power! – Revolutionary effects on society .Annual Sales 1019 transistors manufactured in 2008 – 1 billion for every human on the planet...

45p vanmanh1008 07-06-2013 64 7   Download

Glofish is the first transgenic animal approved to be consumed by human in the USA  The insertion of different constructs of GFP into the fish genomes to give different green colors.The idea for recombinant DNA was first proposed by Peter Lobban, a graduate student of Prof. Dale Kaiser in the Biochemistry Department at Stanford University Medical School. The first publications describing the successful production and intracellular replication of recombinant DNA appeared in 1972 and 1973.

54p zingzing09 24-04-2013 77 5   Download

Thea-melanocyte-stimulating hormone (aMSH) receptor (MC1R) is amajordeterminant ofmammalianskinandhair pigmentation. Binding ofaMSHtoMC1Rinhuman mel-anocytes stimulates cell proliferation and synthesis of pho-toprotective eumelanin pigments. Certain MC1Ralleles have been associated with increased riskof melanoma. This can be theoretically considered on two grounds. First, gain-of-function mutations may stimulate proliferation, thus promoting dysplastic lesions.

9p tumor12 22-04-2013 34 4   Download