The hormones case

Protein aggregation is central to most neurodegenerative diseases, as shown by familial case studies and by animal models. A modified ‘amyloid cas-cade’ hypothesis for Alzheimer’s disease states that prefibrillar oligomers, also called amyloid-b-derived diffusible ligands or globular oligomers, are the responsible toxic agent. It has been proposed that these oligomeric spe-cies, as shown for amyloid-b, b2 -microglobulin or prion fragments, exert toxicity by forming pores in membranes, initiating a cascade of detrimental events for the cell. ...

10p awards 06-04-2013 40 3   Download

In recent studies on heme-copper oxidases a particular glutamate residue in subunit II has been suggested to constitute the entry point of the so-called K pathway. In contrast, mutations of this residue (E78 II ) in the Paracoccus denitrificanscytochromecoxidase do not affect its catalytic activity at all (E78 II Q) or reduce it to about 50% (E78 II A); in the latter case, the mutation causes no drastic decrease in hemea3 reduction kinetics under anaerobic con-ditions, when compared to typical K pathway mutants....

9p awards 05-04-2013 29 4   Download

The primary structure of linkers in a new class of modulara-amylases con-stitutes a paradigm of the structural basis that allows a polypeptide to remain nonfolded, extended and pliable. Unfolding is mediated through a depletion of hydrophobic residues and an enrichment of hydrophilic resi-dues, amongst which Ser and Thr are over-represented.

8p cosis54 05-01-2013 36 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Failure of functional imaging with gallium-68DOTA-D-Phe1-Tyr3-octreotide positron emission tomography to localize the site of ectopic adrenocorticotropic hormone secretion: a case report

4p toshiba24 07-12-2011 60 5   Download