The Potential of the brain

The thesis is the first study which evaluates the results of formultiple organs resuscitation strategy in brain death potential donors. From the results of this study, it is recommended to optimize the hemodynamics to adequately perfusion of organs after brain death to ensure the functions of the transplanted organs later; the organs should be used in the 24 first hours frombeginning of organ resuscitation (about 12 hours after the declaring of Brain-dead diagnosis Council) because the organ functionsare is the best.

27p angicungduoc6 21-07-2020 13 1   Download

Regulator of G-protein signaling (RGS) proteins were originally identified as negative regulators of G-protein-coupled receptor (GPCR) signaling via their GTPase-accelerating protein (GAP) activity. All RGS proteins contain evolutionarily conserved RGS domain; however, they differ in their size and regulatory domains. RGS1 and RGS10 are smaller than other RGS proteins, and their functions involve various inflammatory responses including autoimmune responses in both the periphery and the central nervous system (CNS). Neuroinflammation is the chronic inflammatory response in the CNS.

5p caothientrangnguyen 09-05-2020 28 2   Download

The regulation of adenosine kinase (AK) activity has the potential to control intracellular and interstitial adenosine (Ado) concentrations. In an effort to study the role of AK in Ado homeostasis in the central nervous system, two iso-forms of the enzymewere cloned fromamouse brain cDNA library. Following overexpression in bacterial cells, the cor-responding proteins were purified to homogeneity.

9p awards 05-04-2013 37 2   Download

The extracellular signal regulated protein kinases (ERK1/2) are essential for normal development and functional plasti-city of the central nervous system. However, a growing number of recent studies in models of cerebral ischemia, brain trauma and neurodegenerative diseases implicate a detrimental role for ERK1/2 signaling during oxidative neuronal injury. Neurons undergoing oxidative stress-rela-ted injuries typically display a biphasic or sustained pattern of ERK1/2 activation.

7p dell39 03-04-2013 40 3   Download

Because clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain’s own endogenous strategies for neuroprotection. Two endogenous mechanisms have been characterized so far, namely ischemic preconditioning and ische-mic postconditioning.

12p vinaphone15 27-02-2013 33 2   Download