The structure of a network

This research develops a rich theoretical and empirical understanding of embeddedness by way of three dimensions (structural, relational and cultural), and investigates its implications for actors’ value co-creation behaviours and value-in-context outcomes. In addition, the research refines co-creation perspectives by examining a central boundary condition of co-creation processes. The data was collected in an online service environment and was analysed using structural equation modelling techniques.

183p runthenight04 02-02-2023 9 2   Download

Goals of the dissertation: This thesis focuses on studying and developing meta-heuristic optimization methods and combines them with the Artificial Neural Network, which has advantages in approximating data, to build up a new algorithm for solving composite material structural optimization problems.

136p monsterhunterer 20-06-2021 10 3   Download

In this paper, one-stage and two-stage nonlinear programming problems are investigated in order to evaluate the efficiency of two types of network data envelopment analysis model.

14p tohitohi 22-05-2020 15 1   Download

Communication Systems Lecturer: M.E. P.T.A. Quang .Contents           Chapter 1: Introductory Concepts Chapter 2: QoS Chapter 3: Transmission and switching Chapter 4: Digital networks Chapter 5: Signaling Chapter 6: PSTN Chapter 7: VoIP Chapter 8: Mobile communication Chapter 9: Satellite communication Chapter 10: Fiber-optic communication .

20p vanmanh1008 24-06-2013 108 7   Download

Expansins are a family of proteins that catalyze pHdependent long-term extension of isolated plant cell walls. They are divided into two groups, a and b, the latter consisting of the grass group I pollen allergens and their vegetative homologs. Expansins are suggested to mediate plant cell growth by interfering with either structural proteins or the polysaccharide network in the cell wall.

10p research12 01-06-2013 29 4   Download

Manipulating URLs URL is an acronym for Uniform Resource Locator and is a reference (an address) to a resource on the Internet. Sample structure of a URL. The resource name part may contain: host name, file

15p huanltgc00061 05-05-2013 51 4   Download

In this paper we address the problem of extracting features relevant for predicting protein±protein interaction sites from the three-dimensional structures of protein complexes. Our approach is based on information about evolutionary con-servation and surface disposition. We implement a neural network based system, which uses a cross validation proce-dure and allows the correct detection of 73% of the residues involved in protein interactions in a selected database comprising 226 heterodimers.

6p research12 29-04-2013 31 3   Download

The structurally homologous mononuclear iron and man-ganese superoxide dismutases (FeSOD and MnSOD, respectively) containa highly conservedglutamine residue in the active site which projects toward the active-site metal centre and participates in an extensive hydrogen bonding network. The position of this residue is different for each SOD isoenzyme (Q69 in FeSOD and Q146 in MnSOD of Escherichia coli).

12p tumor12 22-04-2013 47 3   Download

The topology of central carbon metabolism ofAspergillus nigerwas identified and the metabolic network reconstruc-ted, by integrating genomic, biochemical and physiological information available for this microorganism and other related fungi. The reconstructed network may serve as a valuabledatabase for annotationof genes identified in future genome sequencing projects on aspergilli. Based on the metabolic reconstruction, a stoichiometric model was set up that includes 284metabolites and335reactions,...

11p tumor12 20-04-2013 26 3   Download

We introduce the basic concepts and develop a theory for nonequilibrium steady-state biochemical systems applicable to analyzing large-scale complex isothermal reaction networks. In terms of the stoichiometric matrix, we dem-onstrate both Kirchhoff’s flux lawR‘J‘ ¼0 over a bio-chemical species, and potential law R‘l‘ ¼0overa reaction loop. They reflect mass and energy conservation, respectively.

7p tumor12 20-04-2013 45 3   Download

Perhaps the most widely used applications of bioinformatics are tools such as psi-blast for searching sequence databases. We describe a recently developed protein database search algorithm calledrankprop. rankprop relies upon a precomputed network of pairwise protein similarities. The algorithm performs a diffusion operation from a specified query protein across the protein similarity network.

10p fptmusic 12-04-2013 49 3   Download

Due to the unavoidable nonbiological variations accompanying many experiments, it is imperative to consider a way of unravelling the functional interaction structure of a cellular network (e.g. signalling cascades or gene networks) by using the qualitative information of time-series experimental data instead of computation through the measured absolute values.

10p fptmusic 11-04-2013 49 3   Download

Modelling of biochemical systems usually focuses on certain pathways, while the concentrations of so-called external metabolites are considered fixed. This approximation ignores feedback loops mediated by the environ-ment, that is, via external metabolites and reactions. To achieve a more realistic, dynamic description that is still numerically efficient, we propose a new methodology: the basic idea is to describe the environment by a lin-ear effective model of adjustable dimensionality.

10p fptmusic 11-04-2013 33 2   Download

Our laboratory is interested in the biochemical and biophysical basis of cell structure. The structure of a cell is determined primarily by its cytoskeleton, which serves as a scaffold to sup-port the plasma membrane, and as a network of tracks along which motor proteins transport sub cellular structures. Our research is therefore focused on the mechanics of the cytoskele-ton, with a particular emphasis on microtubules and microtu-bule-based motors.

17p fptmusic 11-04-2013 52 3   Download

Nephrin is a signalling cell–cell adhesion protein of the Ig superfamily and the first identified component of the slit diaphragm that forms the critical and ultimate part of the glomerular ultrafiltration barrier. The extracellular domains of the nephrin molecules form a network of homophilic and heterophilic interactions building the structural scaffold of the slit dia-phragm between the podocyte foot processes.

16p awards 05-04-2013 43 4   Download

The classical metabolic control theory [Kacser, H. & Burns, J.A. (1973)Symp.Soc.Exp.Biol. 27, 65–104; Heinrich, R. & Rapoport, T. (1974)Eur. J. Biochem.42, 89–95.] does not take into account experimental evidence for correlations between enzyme concentrations in the cell. We investigated the implications of two causes of linear correlations: competition between enzymes, which is a mere physical adaptation of the cell to the limitation of resources and space, and regulatory correlations, which result from the existence of regulatory networks....

17p awards 05-04-2013 49 3   Download

In view of the increasing number of reported concentration oscillations in living cells, methods are needed that can identify the causes of these oscillations. These causes always derive from the influences that concentrations have on reaction rates. The influences reach over many molecular reaction steps and are defined by the detailed molecular topology of the network. So-called
autoinfluence paths, which quantify the influence of one molecular species upon itself through a particular path through the network, can have positive or negative values....

11p awards 05-04-2013 46 5   Download

Cyclic nucleotide specific phosphodiesterases (PDEs) are important components of all cAMP signalling networks. In humans, 11 different PDE families have been identified to date, all of which belong to the class I PDEs. Pharmaco-logically, theyhavebecome of great interest as targets for the development of drugs for a large variety of clinical condi-tions. PDEs in parasitic protozoa have not yet been exten-sively investigated, despite their potential as antiparasitic drug targets.

11p dell39 03-04-2013 40 4   Download

The discovery of novel biologically active peptides has led to an explosion in our understanding of the molecular mechanisms that underlie the regula-tion of sleep and wakefulness. Urotensin II (UII), a peptide originally isolated from fish and known for its strong cardiovascular effects in mammals, is another surprising candidate in the regulatory network of sleep.

9p dell39 27-03-2013 32 4   Download

The nematocyst capsules of the cnidarians are specialized explosive organelles that withstand high osmotic pressures of
15 MPa (150 bar). A tight disulfide network involving cysteine-rich capsule wall proteins, like minicollagens and nematocyst outer wall antigen, characterizes their molecular composition.

8p inspiron33 25-03-2013 43 3   Download