Therapeutic drug monitoring

Nghiên cứu hồi cứu trên bệnh án của 142 bệnh nhân có sử dụng theo dõi nồng độ thuốc trong máu (TDM, therapeutic drug monitoring) của vancomycin nhằm mục đích khảo sát các đặc điểm chính của bệnh nhân, đặc điểm vi sinh và đặc điểm TDM vancomycin tại Bệnh viện Đa khoa Quốc tế Hải Phòng.

5p vithales 16-04-2022 7 0   Download

While molecularly targeted therapies and immune checkpoint inhibitors have improved the prognosis of advanced melanoma, biomarkers are required to monitor drug responses. Circulating tumor cells (CTCs) are released from primary and/or metastatic tumors into the peripheral blood.

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Clinical studies implying the sunitinib multi-kinase inhibitor have led to disappointing results for breast cancer care but mostly focused on HER2-negative subtypes. Preclinical researches involving this drug mostly concern Triple Negative Breast Cancer (TNBC) murine models.

10p viamsterdam 18-09-2020 7 1   Download

A trough concentration (Cmin) ≥20 μg/mL of teicoplanin is recommended for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections. However, sufficient clinical evidence to support the efficacy of this target Cmin has not been obtained.

10p vidhaka2711 31-07-2020 19 0   Download

(BQ) This book does not aim to be a panacea; many areas of uncertainty in diagnosis and management remain. However, current best practice (at least as practised by us!) is described in succinct, concise, clinically orientated sections, covering therapeutic and monitoring, drugs and fl uids, specifi c organ system disorders and complications, and general management philosophies. Ample space is provided to append or amend sections to suit your particular practice.

315p nanhankhuoctai5 01-06-2020 8 1   Download

Pazopanib is a tyrosine kinase inhibitor indicated for the treatment of renal cell carcinoma and soft tissue sarcoma. Despite the high inter-patient variability in pharmacokinetic exposure, pazopanib is administered at a fixed dose of 800 mg once daily (QD).

3p viputrajaya2711 22-06-2020 6 1   Download

G protein-coupled receptors (GPCRs) are ubiquitous surface proteins mediating various biological responses and thus, important targets for therapeutic drugs. GPCRs individually produce their own signaling as well as modulate the signaling of other GPCRs.

9p viuchiha2711 21-04-2020 7 0   Download

The objective of this study was to evaluate patients with non-deep seated infections treated with short-course vancomycin to determine whether there were differences in outcomes with trough concentrations of ≤10 mg/L (low) versus > 10 mg/L (high).

9p vimax2711 30-03-2020 6 1   Download

Children are subject to varying drug pharmacokinetics which influence plasma drug levels, and hence treatment outcomes especially for drugs like efavirenz whose plasma concentrations are directly related to treatment outcomes.

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This study sought to assess the pharmacokinetic and pharmacodynamic relationships of caffeine citrate therapy in preterm neonates who had therapeutic drug monitoring (TDM) in the post-extubation period.

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Invasive aspergillosis (IA) is a fatal infectious complication among immunocompromised patients. Aspergillus terreus, the fourth common species can be difficult to treat due to a unique resistance pattern. To date, there has been no report on safety and dose adjustment when intravenous posaconazole is selected in hepatic and renal impairment patient.

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In the Netherlands, perinatal asphyxia (severe perinatal oxygen shortage) necessitating newborn resuscitation occurs in at least 200 of the 180–185.000 newly born infants per year. International randomized controlled trials have demonstrated an improved neurological outcome with therapeutic hypothermia.

7p virubber2711 21-03-2020 6 0   Download

Vancomycin is effective against gram-positive bacteria and the first-line antibiotic for treatment of proven coagulase-negative staphylococcal infections. The aim of this study is bipartite: first, to assess the percentage of therapeutic initial trough serum concentrations and second, to evaluate the adequacy of the therapeutic range in interrelationship with the observed MIC-values in neonates.

6p vichengshin2711 29-02-2020 3 0   Download

Ganciclovir is a therapeutic choice for extremely premature infants with severe postnatal cytomegalovirus disease, but little is known about its optimal dose size and dosing interval for them.

4p videshiki2711 21-02-2020 25 1   Download

The prescription of antipsychotics (AP), and especially second generation AP, is increasing worldwide in the pediatric population. Most prescriptions are off-label and despite the identification of frequent and potentially severe adverse events (AE), there are only a few guidelines for the safety management. France is one of the countries with no official safety guidelines.

7p vilisbon2711 07-01-2020 2 0   Download

To design an alternative painless method for vancomycin (VCM) monitoring by withdrawing interstitial fluid (ISF) the skin using dissolving microneedles (DMNs) and possibly replace the conventional clinical blood sampling method.

6p viwashington2711 04-12-2019 7 1   Download

(bq) part 2 book "prescribing at a glance" presentation of content: logistics of prescribing (how to write a drug prescription, communicating with patients about medicines, therapeutic drug monitoring, avoiding drug interactions,...), specific drug groups (using drugs for the respiratory system, using drugs for the neurological system i, using drugs for infection, an approach to common prescribing requests,...).

50p thangnamvoiva23 06-10-2016 52 7   Download

(BQ) Continued part 1, part 2 of the document Wallach's interpretation of diagnostic tests presents the following contents: Renal disorders, respiratory, metabolic and acid–base disorders, toxicology and therapeutic drug monitoring, transfusion medicine, laboratory tests, infectious disease assays.

759p thangnamvoiva3 01-07-2016 59 3   Download

(BQ) Part 1 of the document Clinical chemistry - Quality in laboratory diagnosis presents the following contents: Specimen receiving and processing, core chemistry, therapeutic drug monitoring/toxicology, point-of-Care testing.

108p thangnamvoiva3 28-06-2016 26 0   Download

In this review, will be summarize the principle of these new methodologies and the impact of omics-techniques, mainly genomic-transcriptomics (analysis of single nucleotide polymorphisms or gene-expression) and proteomic (identification and quantification of proteins), in the knowledge of different aspects of allergy diseases (diagnosis, screening, monitoring of treatment, protective or risk biomarkers and drug development) and the advance to define the personalized and molecular medicine in this complex kind of diseases....

344p wqwqwqwqwq 21-07-2012 59 10   Download