Therapeutic drugs

High expression of the glycosyltransferase UGT2B17 represents an independent adverse prognostic marker in chronic lymphocytic leukemia (CLL). It also constitutes a predictive marker for therapeutic response and a drug resistance mechanism.

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Endostar, an anti-angiogenic drug, has been approved for treating non-small cell lung cancer (NSCLC). At present, endostar combined with radiotherapy or chemotherapy has achieved ideal results in the treatment of some tumors, but there is a lack of application and study in NSCLC. This study investigated the therapeutic effect and potential mechanism of endostar combined with cisplatin (EC) in NSCLC.

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The incidence of prostate cancer (PCa), the most prevalent malignancy, is currently at the forefront. RNA modification is a subfield of the booming field of epigenetics. To date, more than 170 types of RNA modifications have been described, and N6-methyladenosine (m6A) is the most abundant and well-characterized internal modification of mRNAs involved in various aspects of cancer progression.

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Investigating novel therapeutic strategies for colorectal cancer (CRC) is imperative. However, there is limited research on the use of drugs to target peripheral blood immune cells in this context. To address this gap, we performed a two-sample Mendelian randomization (MR) analysis to identify potential therapeutic targets for CRC.

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Drug repurposing provides a cost-effective approach to address the need for lung cancer prevention and therapeutics. We aimed to identify actionable druggable targets using Mendelian randomization (MR).

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In this study, we investigated the therapeutic potential of bacteriostatic antibiotics in regulating the growth potential of colorectal cancer (CRC) cells, which differ in their metastatic potential and mitochondrial functions.

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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Acquired functional mutations in the tyrosine-protein kinase growth factor receptor proto-oncogene (KIT) and platelet-derived growth factor-alpha gene lead to increased tyrosine kinase activity, which is considered a key factor in the pathogenesis of GIST.

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Breast carcinoma (BC) ranks as a predominant malignancy and constitutes the second principal cause of mortality among women globally. Epirubicin stands as the drug of choice for BC therapeutics. Nevertheless, the emergence of chemoresistance has significantly curtailed its therapeutic efficacy.

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Predicting tumor responses to neoadjuvant chemotherapy (NAC) is critical for evaluating prognosis and designing treatment strategies for patients with breast cancer; however, there are no reliable biomarkers that can effectively assess tumor responses. Therefore, we aimed to evaluate the clinical feasibility of using extracellular vesicles (EVs) to predict tumor response after NAC.

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Tacrolimus, a calcineurin inhibitor, is a first-choice drug for the anti-rejection treatment regimen after kidney transplantation. The daily adjusted Tacrolimus dose by therapeutic drug monitoring is essential for patients to achieve optimal effects and minimize complications.

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These volumes provide a reference source of different gas chro-matographic, liquid chromatographic, or thin-layer chromatographic techniques for the qualitative determination of various therapeutic agents, including antibiotics, vitamins and hormones, drugs of abuse in body fluids, dosage forms, or food stuffs. Over 5000 publi-cations were reviewed to prepare tables of chromatographic data for 800 compounds, arranged alphabetically by generic drug name or by drug groups.

390p vimeyers 29-05-2024 4 2   Download

The book reviews the classical attributes, compounds, and textual references of Ayurvedic plant drugs and updates the pharmacopoeial attributes of Ayurvedic herbs and formulations to make them more industry-oriented and facilitate their implementation.

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This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development.

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Ebook Interpretation of MS–MS mass spectra of drugs and pesticides includes the following main contents: Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes; This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules; Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others.

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Ebook Pharmacotherapy handbook, tenth edition delivers the essential information students and practitioners need to quickly and confidently make drug therapy decisions for more than 140 of the diseases and disorders most commonly encountered in a clinical setting. Featuring a convenient alphabetized presentation, this handy guide utilizes text, tables, figures, and treatment algorithms to make important drug data readily accessible and easily understood.

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Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor.

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Part 1 book "Goodman and gilmans the pharmacological basis of therapeutics" includes content: General principles, neuropharmacology, modulation of pulmonary, renal, and cardiovascular function, inflammation, immunomodulation, and hematopoiesis

774p zizaybay1101 30-04-2024 2 2   Download

Part 1 book "Clinical pharmacy and therapeutics" includes content: Clinical pharmacy process, practical pharmacokinetics, drug interactions, adverse drug reactions, laboratory data, parenteral nutrition, liver disease, cute kidney injury, chronic kidney disease and end-stage renal disease, coronary heart disease.

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Ebook Clinical pharmacy and therapeutics (5th edition): Part 2 includes content: Parkinson's disease, nausea and vomiting, respiratory infections, urinary tract infections, gastro-intestinal infections, infective meningitis, surgical site infection and antimicrobial prophylaxis, fungal infections, drug-induced skin disorders.

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The aim of the study was to explore how the logistics, micro, market and macro coordination dimensions affect the availability of artemisinin-based combination therapies (ACTs) in general hospitals in Uganda. Following a qualitative approach, a multiple case study strategy was used. Specifically, four focus group discussions, each consisting of 8 respondents were conducted from four purposively selected hospitals.

18p longtimenosee10 26-04-2024 2 1   Download