Therapeutic strategy
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Modulation of DNA damage repair in lung squamous cell carcinoma (LUSC) can result in the generation of neoantigens and heightened immunogenicity. Therefore, understanding DNA damage repair mechanisms holds significant clinical relevance for identifying targets for immunotherapy and devising therapeutic strategies.
15p vishanshan 27-06-2024 1 1 Download
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This review aims to elucidate the intricate role of IgE in pediatric asthma, thereby contributing to a deeper understanding of its pathophysiology and aiding in the development of more effective diagnostic and therapeutic strategies.
11p vikoch 27-06-2024 1 1 Download
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Investigating novel therapeutic strategies for colorectal cancer (CRC) is imperative. However, there is limited research on the use of drugs to target peripheral blood immune cells in this context. To address this gap, we performed a two-sample Mendelian randomization (MR) analysis to identify potential therapeutic targets for CRC.
14p vikoch 27-06-2024 1 1 Download
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Pancreatic ductal adenocarcinoma (PDAC) ranks among the deadliest types of cancer, and it will be meaningful to search for new biomarkers with prognostic value to help clinicians tailor therapeutic strategies.
12p vikoch 27-06-2024 1 1 Download
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Glioma recurrence, subsequent to maximal safe resection, remains a pivotal challenge. This study aimed to identify key clinical predictors influencing recurrence and develop predictive models to enhance neurological diagnostics and therapeutic strategies.
12p vikoch 27-06-2024 1 1 Download
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Predicting tumor responses to neoadjuvant chemotherapy (NAC) is critical for evaluating prognosis and designing treatment strategies for patients with breast cancer; however, there are no reliable biomarkers that can effectively assess tumor responses. Therefore, we aimed to evaluate the clinical feasibility of using extracellular vesicles (EVs) to predict tumor response after NAC.
12p vikoch 27-06-2024 1 1 Download
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Prevention, diagnosis and treatment are the watchwords in stroke research, for basic neuroscientists and clinicians alike. This 2002 book, from the 22nd Princeton Conference on Cerebrovascular Disease, contains contributions from outstanding investigators on numerous topics in stroke research. The contents cover the status and future directions of stroke pathophysiology, diagnosis and treatment, with special emphasis on the molecular and cellular mechanisms of ischaemic cell death and repair, and clinical issues including imaging, risk factors and therapeutic strategies in stroke.
456p vimeyers 29-05-2024 4 2 Download
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The aim of the study was to explore how the logistics, micro, market and macro coordination dimensions affect the availability of artemisinin-based combination therapies (ACTs) in general hospitals in Uganda. Following a qualitative approach, a multiple case study strategy was used. Specifically, four focus group discussions, each consisting of 8 respondents were conducted from four purposively selected hospitals.
18p longtimenosee10 26-04-2024 2 1 Download
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Ebook "Forkhead transcription factors: Vital elements in biology and medicine" provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their knowledge and insights to offer a novel perspective for translational medicine that highlights the role of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders.
283p ladongphongthanh1008 22-04-2024 3 2 Download
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Ebook "Fungal biofilms and related infections: Advances in microbiology, infectious diseases and public health (Volume 3)" covers the latest data available to understand the mechanisms causing the formation of single species fungal biofilms or polymicrobial biofilms involving fungal species; specific chapters present hot topics such as resistance mechanisms and composition and role of the matrix. Moreover, it reviews updated data on biofilms that contain yeasts or filamentous fungi and develop in the human body or in water and may cause infections.
129p tracanhphuonghoa1007 22-04-2024 7 2 Download
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Klebsiella pneumoniae is a leading cause of bloodstream infection (BSI). Strains producing extendedspectrum beta-lactamases (ESBLs) or carbapenemases are considered global priority pathogens for which new treatment and prevention strategies are urgently required, due to severely limited therapeutic options.
16p vibransone 28-03-2024 2 2 Download
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The integration of genomics with immunotherapy has potential value for cancer vaccine development. Given the clinical successes of immune checkpoint modulators, interest in cancer vaccines as therapeutic options has been revived.
9p vioraclene 31-03-2024 4 2 Download
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Prognosis evaluation of advanced breast cancer and therapeutic strategy are mostly based on clinical features of advanced disease and molecular profiling of the primary tumor. Very few studies have evaluated the impact of metastatic subtyping during the initial metastatic event in a prospective study.
15p vibransone 28-03-2024 6 2 Download
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Liver cancer is one of the most commonly diagnosed cancers and the fourth leading cause of cancerrelated death worldwide. Broad-spectrum kinase inhibitors like sorafenib and lenvatinib provide only modest survival benefit to patients with hepatocellular carcinoma (HCC). This study aims to identify novel therapeutic strategies for HCC patients.
15p vibransone 28-03-2024 1 1 Download
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In ebook "Nucleic acid drugs (Advances in Polymer science, Volume 249)" the basic concept of antisense and siRNA strategies is summarized by Dr. Yano of Nippon Shinyaku Co. The antisense strategy can be regarded as the striking NAD concept that was logically innovated in the mid-1970s. Originally, oligonucleotides complementary to mRNAs were thought to physically block translational steps in gene expression resulting in the blocking of protein synthesis.
189p coduathanh1122 27-03-2024 1 1 Download
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Ebook "Sodium channels and neuronal hyperexcitability" explains how these channels are modulated in various pathological states to enable the development of therapeutic strategies based on sodium channel restoration. The authors present the most current research on sodium channels and neuronal function. Brings together both the basic biology and biophysics with detailed consideration of the medical applications in chronic pain and epilepsy.
267p coduathanh1122 27-03-2024 2 1 Download
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Alternative splicing complexity plays a vital role in carcinogenesis and cancer progression. Improved understanding of novel splicing events and the underlying regulatory mechanisms may contribute new insights into developing new therapeutic strategies for colorectal cancer (CRC).
24p vicwell 29-02-2024 2 2 Download
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Part 3 book "Large animal internal medicine" includes content: Diseases of the hematopoietic and hemolymphatic systems; diseases of the bones, joints, and connective tissues; diseases of the eye; diseases of the skin; endocrine and metabolic diseases; diseases of muscle; diseases of the reproductive system;...and other contents.
862p muasambanhan08 23-02-2024 1 1 Download
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In ebook "Prion proteins (Topics in current chemistry, Volume 305)" we have assembled a set of chapters highlighting various aspects of prion diseases in humans and animals which show the intriguing features of both physiological and pathogenic PrP conformers. In addition, a wide spectrum of methodological approaches are described, ranging from in silico, chemical, and in vitro approaches to animal models, to illustrate the elaborate and extensive technology established in the prion field, allowing the analysis of disease mechanisms and the development of diagnostic and therapeutic strategies.
308p manmanthanhla0201 26-02-2024 11 1 Download
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Ebook "Human nucleotide expansion disorders" represents a comprehensive and up-to-date description of many of the better-studied disorders. The expert authors discuss molecular, clinical and pathological aspects of the diseases as well as our current understanding of their underlying mechanisms. Of special interest are ideas and initial results of the different therapeutic strategies that can be employed to overcome some of the disorders.
296p manmanthanhla0201 27-02-2024 5 2 Download