Therapeutic use

Proprotein convertase subtilisin/kexin type 9 (PCSK9), the last member of the proprotein convertase family, functions as a classic regulator of low-density lipoprotein (LDL) by interacting with low-density lipoprotein receptor (LDLR). Recent studies have shown that PCSK9 can affect the occurrence and development of tumors and can be used as a novel therapeutic target. However, a comprehensive pan-cancer analysis of PCSK9 has yet to be conducted.

13p vishanshan 27-06-2024 1 1   Download

Although substantial efforts have been made to build molecular biomarkers to predict radiation sensitivity, the ability to accurately stratify the patients is still limited. In this study, we aim to leverage large-scale radiogenomics datasets to build genomic predictors of radiation response using the integral of the radiation dose–response curve.

10p vishanshan 27-06-2024 1 1   Download

Investigating novel therapeutic strategies for colorectal cancer (CRC) is imperative. However, there is limited research on the use of drugs to target peripheral blood immune cells in this context. To address this gap, we performed a two-sample Mendelian randomization (MR) analysis to identify potential therapeutic targets for CRC.

14p vikoch 27-06-2024 1 1   Download

Drug repurposing provides a cost-effective approach to address the need for lung cancer prevention and therapeutics. We aimed to identify actionable druggable targets using Mendelian randomization (MR).

10p vikoch 27-06-2024 1 1   Download

Predicting tumor responses to neoadjuvant chemotherapy (NAC) is critical for evaluating prognosis and designing treatment strategies for patients with breast cancer; however, there are no reliable biomarkers that can effectively assess tumor responses. Therefore, we aimed to evaluate the clinical feasibility of using extracellular vesicles (EVs) to predict tumor response after NAC.

12p vikoch 27-06-2024 1 1   Download

The book also describes what cerebral monitoring can do and what its limitations are. In addition, proper selection of the available monitoring devices, set-up procedures, the technique of electrode placement, trouble shooting and data interpretation are fully covered. Various typical cases underline how EEG power spectra and evoked potential changes are interpreted, how they are used in the light of other variables being measured how they can serve to get a deeper insight into the underlying clinical situation.

183p vimeyers 29-05-2024 3 2   Download

Pluchea pteropoda, an annual plant in the Asteraceae family, has traditionally been used in Vietnamese folk medicine as an alternative treatment for high fever, indigestion, and painful and swollen wounds. The present study investigates the acute toxicity and antiinflammatory effects of P. pteropoda aerial parts ethanol extract (EtPP) in animal models. EtPP exhibited no toxicity in mice with a single dose of up to 5000 mg/kg.

5p vicarlos 16-05-2024 0 0   Download

The aim of the study was to explore how the logistics, micro, market and macro coordination dimensions affect the availability of artemisinin-based combination therapies (ACTs) in general hospitals in Uganda. Following a qualitative approach, a multiple case study strategy was used. Specifically, four focus group discussions, each consisting of 8 respondents were conducted from four purposively selected hospitals.

18p longtimenosee10 26-04-2024 2 1   Download

Ebook "Advances in stem cell research" discusses recent advances in stem cell science, including therapeutic applications. This volume covers such topics as biomanufacturing iPS cells for therapeutic applications, techniques for controlling stem cell fate decisions, as well as current basic research in such areas as germ line stem cells, genomics and proteomics in stem cell research. It is a useful book for biology and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research.

401p ladongphongthanh1008 22-04-2024 4 2   Download

Ebook "Regenerative medicine and cell therapy" discusses cutting-edge science in the field of regenerative biomedicine and its therapeutic applications to various medical disorders. The chapters are written by renowned scientists in the specific fields. This will be a useful book for basic and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research.

322p ladongphongthanh1008 22-04-2024 3 1   Download

Ebook "Kisspeptin signaling in reproductive biology" is to summarize and celebrate the key fi ndings from the past decade of kisspeptin research, as well as stimulate both future experimentation and further re fi nement of clinical use of kisspeptin for medical and therapeutic endeavors.

514p tracanhphuonghoa1007 22-04-2024 3 1   Download

Ebook "Oxidative stress in cancer biology and therapy" in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications.

465p tracanhphuonghoa1007 22-04-2024 2 2   Download

Ebook "New frontiers in organoselenium compounds" presents recent advances in and perspectives on the use of organoselenium compounds, primarily highlighting the new frontiers in the field of Green Chemistry, their therapeutic and biological relevance and new materials. Throughout its 200 pages, readers will find an updated and comprehensive review of new aspects of organoselenium chemistry and biochemistry.

194p tracanhphuonghoa1007 22-04-2024 3 2   Download

Psychosocial and educational intervention approaches employ diverse treatment frameworks, most of which involve delivering some form of feedback to participants about their behavior. General conceptions of feedback are well-known to underlie mainstream therapeutic and educational approaches. Recently emerging ‘smart’ approaches also rely on feedback principles.

13p viarnault 25-04-2024 4 2   Download

Part 2 book "Decision making in veterinary practice" includes content: The influence of patient weight on decision making, the influence of age and aging on decision making, the day of the week matters, the time of day matters, serial monitoring of laboratory results, overdiagnosis and useful diagnosis,... and other contents.

133p muasambanhan10 03-04-2024 2 0   Download

Part 2 book "Fundamentals and applications of controlled release drug delivery" includes content: Targeted delivery using biodegradable polymeric nanoparticles; liposomes in drug delivery; receptor mediated delivery systems for cancer therapeutics, biological rhythms, drug delivery, and chronotherapeutics; site specific controlled release for cardiovascular disease - translational directions; drug delivery systems to fight cancer; fundamentals of vaccine delivery in infectious diseases; tissue engineering in drug delivery.

340p muasambanhan10 03-04-2024 1 0   Download

Tumor cell-intrinsic mechanisms and complex interactions with the tumor microenvironment contribute to therapeutic failure via tumor evolution. It may be possible to overcome treatment resistance by developing a personalized approach against relapsing cancers based on a comprehensive analysis of cell typespecific transcriptomic changes over the clinical course of the disease using single-cell RNA sequencing (scRNA-seq).

21p vibransone 28-03-2024 3 2   Download

Dietary glycans, widely used as food ingredients and not directly digested by humans, are of intense interest for their beneficial roles in human health through shaping the microbiome. Characterizing the consistency and temporal responses of the gut microbiome to glycans is critical for rationally developing and deploying these compounds as therapeutics.

16p vibransone 28-03-2024 6 2   Download

Next-generation sequencing (NGS) of cancer gene panels are widely applied to enable personalized cancer therapy and to identify novel oncogenic mutations. Methods: We performed targeted NGS on 932 clinical cases of non-small-cell lung cancers (NSCLCs) using the Ion AmpliSeq™ Cancer Hotspot panel v2 assay.

11p vioraclene 31-03-2024 3 2   Download

Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response. Previous genome-wide studies have focused on identifying factors explaining variance in stable dose, but have not explored the initial patient response to warfarin, and a wider range of clinical and biochemical factors affecting both initial and stable dosing with warfarin.

12p vioraclene 31-03-2024 9 2   Download