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Toxicity test
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The GLP regulations have developed from rules on how to exactly document the planning, conduct and reporting of toxicity studies to a quality system for the management of a multitude of study types, from the simple determination of a physical/chemical parameter to the most complex field tests or ecotoxicology studies. At the same time the term "Good Laboratory Practice" has become somewhat of a slogan with the aim to characterise any reliably conducted laboratory work.
432p
vimeyers
29-05-2024
5
2
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The increased exposure to toxins, toxicants and novel drugs has promoted toxicology to become one of the most important areas of research with emerging innovative toxicity testing protocols, techniques, and regulation being placed.
236p
vimeyers
29-05-2024
5
2
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This study, a range of temperatures, lighting periods and salinity levels were examined for cyst hatching. The quality nauplii from optimized cyst hatching conditions were used to determine the toxicity of 26 methanol extracts of 24 poisonous plant species collected from the mountainous regions in Quang Tri province of Vietnam.
13p
dianmotminh02
03-05-2024
2
1
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The present study was performed to gather information on the effects of Kovir capsules on reproductive and developmental parameters in mice according to the OECD guideline for reproductive/developmental toxicity screening test.
9p
vilarry
12-03-2024
1
1
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Ebook A textbook of modern toxicology (Fourth edition): Part 2 includes content: Hepatotoxicity, toxicology of the nervous system, reproductive system, endocrine toxicology, respiratory toxicology, immune system, toxicity testing, forensic and clinical toxicology,… and other contents. Invite you to refer.
374p
longtimenosee03
01-02-2024
2
0
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Part 2 book "Feline medicine - Review and test" includes content: Urinary tract disorders; endocrinological disorders; neurological disorders; toxicity and trauma; miscellaneous disorders.
194p
oursky10
04-12-2023
5
2
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Part 1 book "Biomarkers in toxicology" includes content: Introduction, rodent models for toxicity testing and biomarkers, gottingen minipigs as large animal model in toxicology, nonhuman primates in preclinical research, mechanistic toxicology biomarkers in caenorhabditis elegans, potential of small animals in toxicity testing - hope from small world,.... and other contents.
628p
oursky08
06-11-2023
4
3
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Dihydropyrimidine dehydrogenase (DPD) is a key enzyme in the metabolism of fluoropyrimidines. Variations in the encoding DPYD gene are associated with severe fluoropyrimidine toxicity and up-front dose reductions are recommended. We conducted a retrospective study to evaluate the impact of implementing DPYD variant testing for patients with gastrointestinal cancers in routine clinical practice in a high volume cancer centre in London, United Kingdom.
8p
visharma
20-10-2023
4
2
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Part 1 book "The nonhuman primate in nonclinical drug development and safety assessment" includes content: The role of nonhuman primates in safety assessment regulatory toxicology, translational aspects for the use of nonhuman primates in drug development, nonhuman primate specifica spects of standard toxicology studies, special toxicity testing with nonhuman primates, future trends in primate toxicology.
372p
oursky05
20-09-2023
2
1
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Precise prognostication is the key to optimum and effective treatment planning for early-stage hormone receptor (HR) positive, HER2/neu negative breast cancer patients. Differences in the breast cancer incidence and tumor anatomical features at diagnosis, pharmacogenomics data between Western and Indian women along with the vast diversity in the economic status and differences in insurance policies of these regions.
11p
vioracle
29-09-2023
2
2
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Part 2 book "Modern medical toxicology" includes content: Cardiac drugs and lipid lowering agents, anticoagulants and related drugs, cardiotoxic plants, toxic gases, miscellaneous drugs and poisons, hydrocarbons and pesticides, gastrointestinal and endocrinal drugs, substances of dependence and abuse, . biochemical and haematological tests, analytical instrumentation, food poisoning.
317p
oursky02
06-08-2023
5
2
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This study was conducted to assess the toxicity of the sulfur mustard military chemical to the growth and development of zooplankton Daphnia magna. D. magna is a group of crustaceans which have unique features such as virgin reproduction/ parthenogenesis form in a short time, easy to identify and control toxic substances so they are usually used as a standard model organism for toxicity testing in aquatic environments.
9p
viberkshire
09-08-2023
6
3
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In this study, the combination of Fe(III) and Ni(II), Cu(II), or Mn(II) metal salts bound to organic bridges were synthesized based on thermal method solvent in the presence of DMF. The structural properties of the materials were analyzed based on modern physicochemical methods (XRD, FT-IR, SEM, and BET).
8p
vidoctorstrange
06-05-2023
7
3
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RAD140 (Testalone) is a novel selective androgen receptor modulator with very limited data currently available on adverse effects related to this compound. The first-in-human phase 1 trial was recently published and did report a significant proportion of elevated aspartate aminotransferase, alanine transaminase, and total bilirubin among the test subjects.
3p
vidoctorstrange
06-05-2023
3
2
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In this research, a combined photocatalytic and biological treatment is proposed for the elimination of pollutants present in textile wastewater using a natural erionite zeolite (PE) and aluminum oxide (PA) synthesized by the sol-gel method as photocatalysts, and solar radiation. Both catalysts were characterized by XRD, SEM, and EDS. For biological treatment two bacterial consortium were used: BC1 (Escherichia coli N16, Serratia k120, Pseudomonas putida B03 and Enterobacter hormaechei), and consortium BC2 (Escherichia coli N16, Serratia Mc107, Enterobacter N9, Enterobacter hormaechei Mc9).
11p
lyhuyenthu
31-01-2023
7
2
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The acute toxicity, cytotoxicity, genotoxicity and antigenotoxic effects of BC were studied. Cytotoxicity of BC was evaluated in cultured C3A hepatoma cells (HepG2/C3A) using a lactate dehydrogenase (LDH) activity assay. Acute toxicity was tested in adults Wistar rats treated with a single dose of BC.
5p
vihermione
06-01-2023
13
3
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The metal aluminium (Al) is a well-documented neurotoxin and has been known to exacerbate excitotoxicity within the human nervous system. This present research is aimed and intended at assessing the neuroprotective effect of eugenol (EG) against the toxic effects of aluminium chloride (AlCl3) in vivo using Wistar rats as a study model.
14p
viporsche
28-10-2022
3
2
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To independently assess the impact of mandatory testing using an extended DPYD variant panel (ToxNav®) and consequent dose adjustment of Capecitabine/5-FU on recorded quantitative toxicity, symptoms of depression, and hospital costs.
11p
vikolindagrabar
27-07-2022
3
1
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A novel device for supine positioning in breast radiotherapy for patients with large or pendulous breasts has been developed and tested in phase II studies. This trial is designed to assess the efficacy of the device to reduce skin toxicity and unwanted normal tissue dose in comparison to the current clinical standard for supine breast support during breast radiotherapy.
14p
visusanwojcicki
28-06-2022
12
2
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Pharmacogenetic (PGx) testing for germline variants in the DPYD and UGT1A1 genes can be used to guide fuoropyrimidine and irinotecan dosing, respectively. Despite the known association between PGx variants and chemotherapy toxicity, preemptive testing prior to chemotherapy initiation is rarely performed in routine practice.
8p
vielonmusk
21-01-2022
9
0
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