Transcription factor cooperation
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Transcription factors are essential regulators of gene expression and play critical roles in development, differentiation, and in many cancers. To carry out their regulatory programs, they must cooperate in networks and bind simultaneously to sites in promoter or enhancer regions of genes. We hypothesize that the mRNA co-expression patterns of transcription factors can be used both to learn how they cooperate in networks and to distinguish between cancer types.
14p vitzuyu2711 29-09-2021 11 1 Download
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Development of the face and mouth is orchestrated by a large number of transcription factors, signaling pathways and epigenetic regulators. While we know many of these regulators, our understanding of how they interact with each other and implement changes in gene expression during orofacial development is still in its infancy. Therefore, this study focuses on uncovering potential cooperation between transcriptional regulators and one important signaling pathway, retinoic acid, during development of the midface.
23p vitzuyu2711 29-09-2021 17 1 Download
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Chromosomal architecture, which is constituted by chromatin loops, plays an important role in cellular functions. Gene expression and cell identity can be regulated by the chromatin loop, which is formed by proximal or distal enhancers and promoters in linear DNA (1D).
13p visilicon2711 20-08-2021 8 1 Download
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Transcription factor binding to the regulatory region of a gene induces or represses its gene expression. Transcription factors share their binding sites with other factors, co-factors and/or DNA-binding proteins.
9p vijeeni2711 30-06-2021 11 1 Download
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Transcription factors (TFs) are important regulatory proteins that govern transcriptional regulation. Today, it is known that in higher organisms different TFs have to cooperate rather than acting individually in order to control complex genetic programs.
21p vioklahoma2711 19-11-2020 11 3 Download
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Hypoxia is an important factor in tumor angiogenesis, metastasis, and resistance to chemotherapy or radiotherapy, and may be an indicator of poor prognosis. The transcription factor hypoxia-inducible factor 1 (HIF-1) is the key regulator of the hypoxic state. This study was designed to evaluate the prognostic value of HIF-1α expression in small cell lung cancer (SCLC).
6p vicaracas2711 27-11-2019 11 0 Download
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The innate antiviral response requires the induction of genes and proteins with activities that limit virus replication. Among these, the well-character-ized interferon b (IFNB) gene is regulated through the cooperation of AP-1, NF-jB and interferon regulatory factor 3 (IRF-3) transcription fac-tors. Using a constitutively active form of IRF-3, IRF-3 5D, we showed previously that IRF-3 also regulates an IFN-independent antiviral response through the direct induction of IFN-stimulated genes.
12p fptmusic 11-04-2013 28 1 Download
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Theinterferon-bpromoter has been studied extensively as a model system for combinatorial transcriptional regulation. Invirus-infectedcells the transcription factorsATF-2, c-Jun, interferon regulatory factor (IRF)-3, IRF-7andNF-jB, and the coactivators p300/CBP play critical roles in the activa-tion of this and other promoters. It remains unclear, how-ever, why most other combinations of AP-1, IRF and Rel proteins fail to activate theinterferon-bgene. Here we have explored how different IRFs may cooperate with other fac-tors to activate transcription....
11p awards 05-04-2013 38 3 Download
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Although allostery plays a central role in driving protein–DNA interac-tions, the physical basis of such cooperative behavior remains poorly understood. In the present study, using isothermal titration calorimetry in conjunction with site-directed mutagenesis, we provide evidence that an intricate network of energetically-coupled residues within the basic regions of the Jun-Fos heterodimeric transcription factor accounts for its allosteric binding to DNA.
15p cosis54 05-01-2013 33 2 Download