Treatment duration

We aimed to identify the T790M mutation rate and clinical factors predicting the occurrence of acquired T790M mutations in advanced non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations after first- and secondgeneration tyrosine kinase inhibitor (TKI) treatment.

9p vicarlos 16-05-2024 1 0   Download

In the compressed wood production technology, the heat treatment for dimensional stability of compressed wood plays an important role as it reduces tension in the wood after shape transformed compressing. This study has mentioned the effects of temperature (160.170, 180, 190, 200, 210o C) and duration (0.5, 2.5, 4.5, 6.5, 8.5h) of treatment of Styrax tonkinensis woodin a vacuum condition of 650mmHg.

12p vilarry 01-04-2024 1 1   Download

The aims of this study focusing on Locoregionally advanced nasopharyngeal carcinoma (LANPC) were mainly two-fold: on the one hand, to establish a cut-of value to differentiate early and late failure based on prognosis after recurrence or metastasis; and on the other hand, to investigate the duration of concurrent cisplatin benefit over follow-up time.

14p vileonardodavinci 23-12-2023 6 2   Download

The use of Anti-PD-1 therapy has yielded promising outcomes in hepatocellular carcinoma (HCC). However, limited research has been conducted on the overall survival (OS) of patients with varying tumor responses and treatment duration.

11p vialfrednobel 23-12-2023 5 3   Download

In this study, we will summarize the results of several studies on the harmful effects of prolonged high-dose use of paracetamol on sperm number, quality, portability and testicular morphology in experimental animals and humans.

15p vispacex 16-11-2023 3 2   Download

PRECONNECT was an international, phase IIIb trial evaluating the safety and efficacy of trifluridine/tipiracil (FTD/TPI) for metastatic colorectal cancer (mCRC). Patients with mCRC received FTD/TPI 35mg/m2 twice-daily on days 1–5 and 8–12 of each 28-day cycle for third- or later-line treatment.

11p vischultz 20-10-2023 6 1   Download

The α2-adrenergic agonists (dexmedetomidine and clonidine) have been used in several different clinical scenarios in infants and children including sedation during mechanical ventilation, procedural sedation, supplementation of postoperative analgesia, prevention of emergence delirium, control of post-anesthesia shivering, treatment of withdrawal and prolonging of duration of neuraxial anesthesia.

4p viintuit 26-09-2023 1 0   Download

This study aimed to evaluate characteristics of electrolyte disturbances at admission and related factors in the severe burn patient. A retrospective study was carried out on 241 burn patients with burn extent > 20% of BSA, hospitalized at Vietnam National Burn Hospital for 2 years (2021 - 2022) with treatment duration > 3 days.

6p vihulk 28-07-2023 3 2   Download

Antibiotics administered incorrectly may result in detrimental consequences, such as prolonging treatment duration, causing adverse effects, or even increasing mortality. The research aimed to examine the characteristics of the antibiotics list utilized at PDHC in 2019.

7p viwarmachine 03-07-2023 3 2   Download

Levodopa therapy is the standard pharmacological treatment for Parkinson’s disease (PD). However, after an initial period of significant benefit, the effects of levodopa begin to wear off. This results in a reduction in the effect duration and the development of motor complications.

5p viwhitewolf 03-07-2023 4 2   Download

Prognostic indicators, treatments, and survival estimates vary by cancer type. Therefore, disease-specific models are needed to estimate patient survival. Our primary aim was to develop models to estimate survival duration after treatment for skeletal-related events (SREs) (symptomatic bone metastasis, including impending or actual pathologic fractures) in men with metastatic bone disease due to prostate cancer.

11p vikolindagrabar 27-07-2022 3 1   Download

To evaluate the efficacy of platelet-rich plasma in combination with human mesenchymal stem cells from autologous adipose tissue for knee osteoarthritis treatment. Research object and method: In the study, there are 30 patients including 26 females and 4 males; correspondingly, 60 knee joints were diagnosed with osteoarthritis according to the American College of Rheumatology (ACR) who are at the mean age of 58,63 ± 11.11, disease duration is from 5,3± 4,6 years which is respectively of stages II - III according to Kellgren and Lawrence.

12p visusanwojcicki 22-06-2022 8 2   Download

Avoidance of unnecessary antimicrobial administration is a key tenet of antimicrobial stewardship; knowing the optimal duration of therapy obviates over-treatment. However, little research has been performed to establish course lengths for common canine infections. In clinical practice, antimicrobial therapy is frequently prescribed in dogs presenting lower urinary tract signs (haematuria, pollakiuria and dysuria/stranguria).

12p vidarwin 23-02-2022 11 2   Download

Studies suggest a high prevalence of pain in head and neck cancer (HNC) patients at diagnosis, during and after treatment; However, these studies had small sample sizes and did not comprehensively assess factors known to influence pain. We surveyed a large cohort of HNC survivors to determine variations in the prevalence of pain, its treatment and management by duration of survivorship, and assessed a comprehensive list of risk factors.

11p vielonmusk 21-01-2022 10 1   Download

In this study, the Perovskite material CH3NH3PbI3 was prepared using two-step sequential solution deposition technique. The treatment condition for Perovskite film including dipping duration, reaction temperature and annealing temperature was studied. Crystal structure, grain size, and purity of the prepared material were examined using XRD and SEM methods.

6p paddington36 04-01-2022 27 0   Download

This paper proposes a new method of mix design for UHPC using high volume fly ash (HVFA), that is referred to the particle packing optimization of the Compressive Packing Model proposed by F. de Larrard. This proposed method also considers the heat treatment curing duration to maximize the compressive strength of HVFA UHPC.

12p inception36 30-11-2021 15 0   Download

In contrast to head and neck squamous cell carcinoma (HNSCC), the effect of treatment duration in HNSCC-CUP has not been thoroughly investigated. Thus, this study aimed to assess the impact of the time interval between surgery and adjuvant therapy on the oncologic outcome, in particular the 5-year overall survival rate (OS), in advanced stage, HPV-negative CUPs at a tertiary referral hospital.

10p vimahuateng 26-11-2021 12 1   Download

This study aims to establish promising and simple MNP-based protocol for gene delivery initially. Specifically, we aim to evaluate whether sodium chloride (NaCl) could enhance gene transfer with naked plasmid DNA without the need to combine liposomes or polymersomes.

8p spiritedaway36 28-11-2021 10 1   Download

The study here investigated quantitative ultrasound (QUS) parameters to assess tumour response to ultrasound-stimulated microbubbles (USMB) and hyperthermia (HT) treatment in vivo. Mice bearing prostate cancer xenografts were exposed to various treatment conditions including 1% (v/v) Definity microbubbles stimulated at ultrasound pressures 246 kPa and 570 kPa and HT duration of 0, 10, 40, and 50 min.

10p vimahuateng 26-11-2021 3 1   Download

Swallowing therapy is commonly provided as a treatment to lessen the risk or severity of dysphagia secondary to radiotherapy (RT) for head and neck cancer (HNC); however, best practice is not yet established. This trial will compare the effectiveness of prophylactic (high and low intensity) versus reactive interventions for swallowing in patients with HNC undergoing RT.

16p vimahuateng 26-11-2021 8 2   Download