Upstream regulator factors
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Acute lung injury (ALI) is a pulmonary disorder that leads to acute respiration failure and thereby results in a high mortality worldwide. Increasing studies have indicated that toll-like receptor 4 (TLR4) is a promoter in ALI, and we aimed to explore the underlying upstream mechanism of TLR4 in ALI.
15p vimackenziebezos 29-11-2021 9 1 Download
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Characterization of the human RFX transcription factor family by regulatory and target gene analysis
Evolutionarily conserved RFX transcription factors (TFs) regulate their target genes through a DNA sequence motif called the X-box. Thereby they regulate cellular specialization and terminal differentiation. Here, we provide a comprehensive analysis of all the eight human RFX genes (RFX1–8), their spatial and temporal expression profiles, potential upstream regulators and target genes.
15p vibeauty 23-10-2021 10 0 Download
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Diverse stresses including genotoxic therapy can induce proliferating cancer cells to undergo cellular senescence and take on the characteristic phenotypes of replicative cellular aging. This accelerated or therapyinduced senescence has been alternatively proposed to contribute to therapeutic efficacy or resistance.
12p visilicon2711 20-08-2021 7 1 Download
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Transcription of the yeast retrotransposon Ty2-917 is regulated by a complex set of regulatory regions located both upstream and downstream of the transcription initiation site. In this study, it was found that certain chromatin modifying factors are essential for the transcriptional regulation of Ty2-917.
6p vitamix 15-02-2019 18 1 Download
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Our laboratory showed that bikunin, aKunitz-type protease inhibitor, suppresses 4b-phorbol 12-myristate 13-acetate (PMA)- or tumor necrosis factor-alpha (TNFa)-induced urokinase-type plasminogen activator (uPA) expression in different cell types. In addition to its effects on protease inhibition, bikunincouldbemodulatingother cellular events associated with the metastatic cascade.
13p research12 23-04-2013 40 1 Download
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We have identifiedDNA sequences required for the expres-sion of thepresenilin 1(PS1) gene. A promoter region has been mapped in SK-N-SH cells and includes sequences be-tween)118and+178flankingthemajor initiationsite (+1). ThePS1gene is also efficiently transcribed in the SH-SY5Y subclone of SK-N-SH cells. However the promoter appears tobeutilized inalternativeways inbothcell types. Sequences both upstream as well as downstream from the initiation site mapped in SK-N-SH cells were shown by 5¢-and3¢-deletion analysis to play a crucial role in both cell lines....
10p awards 05-04-2013 22 2 Download
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Pokemon, the POK erythroid myeloid ontogenic factor, not only regulates the expression of many genes, but also plays an important role in cell tumorigenesis. To investigate the molecular mechanism regulating expres-sion of the Pokemongene in humans, its 5¢-upstream region was cloned and analyzed.
14p media19 06-03-2013 31 1 Download
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The expression of the six types of human Hb subunits over time is cur-rently considered to be regulated mainly by transcription factors that bind to upstream control regions of the gene (the ‘extrinsic’ component of regu-lation).
9p cosis54 08-12-2012 41 1 Download