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Urate crystals
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Gout is an inflammatory type of arthritis caused by the deposition of crystals of monosodium urate monohydrate (MSU) in the joints. The arthritis is mediated by the release of proinflammatory cytokines including IL-1β, TNF-α and IL-6 by leukocytes including macrophages.
6p
vicaptainmarvel
21-04-2023
6
2
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Chondroitin Sulphate (CS), a natural glycosaminoglycan of the extracellular matrix, has clinical benefit in symptomatic osteoarthritis but has never been tested in gout. In vitro, CS has anti-inflammatory and positive effects on osteoarthritic chondrocytes, synoviocytes and subchondral bone osteoblasts, but its effect on macrophages is unknown.
6p
viannito2711
20-04-2021
10
1
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Gout is a chronic disease of monosodium urate (MSU) crystal deposition. Although hyperuricaemia is the central risk factor for development of gout, not all people with hyperuricaemia have subclinical MSU crystal deposition or indeed, symptomatic disease.
11p
vioregon2711
22-02-2021
14
2
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Ten birds from local poultry farm were brought to Division of Veterinary Pathology, SKUAST-J for necropsy examination. Postmortem examination revealed a white chalky material deposit on pericardial sac, liver, spleen and kidneys. Moreover enlargement of kidneys with necrotic foci was also evident, along with swelling of ureter in some birds. Tissue samples were collected in absolute alcohol from affected organs for histopathological examination and it was diagnosed as visceral gout from gross findings and presence of bluish coloured crystal on histopathological examination.
4p
cothumenhmong9
18-01-2021
9
1
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A six year old male Dalmatian dog was presented with the history of not voiding urine and gradual distention of abdomen for three days. The dog showed fever and distended urinary bladder. Haematobiochemical findings were leukocytosis with neutrophilia and elevated BUN and creatinine. Radiography and ultrasonography showed distended urinary bladder with cystoliths. Cystocentesis followed by retrograde urohydropropulsion was performed and 350 ml of cloudy urine was collected by catheterization.
5p
cothumenhmong5
17-05-2020
9
1
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Deposition of monosodium urate (MSU) crystals in the joint or synovium is the major factor in Gouty arthritis (GA). The clinical features of chronic and recurrent GA include pain and the subsequent development of chronic tophaceous GA with multiple tophi deposits accompanied by osteolysis. The majority of previous animal studies have focused on MSU-induced acute GA without making observations regarding osteolysis.
12p
partimesinhvien
08-05-2020
8
1
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: High-density lipoproteins downregulate CCL2 production in human fibroblast-like synoviocytes stimulated by urate crystals...
10p
thulanh14
19-10-2011
36
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Melanocortin peptides inhibit urate crystal-induced activation of phagocytic cells...
8p
thulanh15
18-10-2011
40
2
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes...
13p
thulanh14
15-10-2011
54
1
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels...
9p
thulanh13
15-10-2011
64
1
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