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Various autoimmune diseases
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Immunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc) are rare autoimmune diseases characterized by the presence of CD4+ cytotoxic T cells in the blood as well as inflammation and fibrosis in various organs, but they have no established etiologies.
14p
vibransone
28-03-2024
4
2
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Rheumatoid Arthritis (RA) is one of the most common autoimmune diseases, affecting approximately 1% of the UK adult population. Patients suffer considerable pain, stiffness and swelling and can sustain various degrees of joint destruction, deformity, and significant functional decline.
15p
vianttinic2711
20-04-2021
11
1
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Adipose-derived stem cells (ASCs) are mesenchymal stem cells (MSCs) derived from adipose tissue. MSCs have multiple properties including anti-inflammatory and immunomodulatory effects in various disease models and human diseases. However, the mechanisms underlying this wide range of effects need to be explored.
9p
vioregon2711
22-02-2021
6
1
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Cytokines act by binding to specific receptors in the plasma membrane of target cells. Knowledge of cytokine–receptor interaction (CRI) is very important for understanding the pathogenesis of various human diseases—notably autoimmune, inflammatory and infectious diseases—and identifying potential therapeutic targets.
16p
vikentucky2711
24-11-2020
11
1
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The Human Microbiome has been variously associated with the immune-regulatory mechanisms involved in the prevention or development of many non-infectious human diseases such as autoimmunity, allergy and cancer.
12p
vioklahoma2711
19-11-2020
12
1
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Regulator of G-protein signaling (RGS) proteins were originally identified as negative regulators of G-protein-coupled receptor (GPCR) signaling via their GTPase-accelerating protein (GAP) activity. All RGS proteins contain evolutionarily conserved RGS domain; however, they differ in their size and regulatory domains. RGS1 and RGS10 are smaller than other RGS proteins, and their functions involve various inflammatory responses including autoimmune responses in both the periphery and the central nervous system (CNS). Neuroinflammation is the chronic inflammatory response in the CNS.
5p
caothientrangnguyen
09-05-2020
22
1
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The Hallmark of Autoimmune diseases is the pathologic activity of the immune system of an organism directed against its own cells and tissues. The disease is a direct consequence of tissue and/or organ damage as mediated by auto reactive components of the immune system, that is, auto reactive T lymphocytes and/or auto antibodies. For diagnostic purposes, auto antibodies are the most important analytes.
5p
kethamoi4
16-04-2020
12
1
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CD8+CD28-T cells (CD8Ts) exert immunosuppressive effects in various autoimmune diseases. The current study was designed to investigate the role of defects in CD8Ts in liver transplantation (LT). The proportion of CD8Ts in peripheral blood was determined by flow cytometry.
8p
vihasaki2711
12-11-2019
11
0
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Students conduct mechanistic and translational research on: the causes of breast, liver, lung and prostate cancer, inflammatory processes in cardiomyopathy, signal pathway disruption in cardiac hypertrophy, chronic obstructive pulmonary disease (COPD), autoimmunity, neurodevelopmental disorders and identification of pathways of toxicity. Seminars, journal clubs and research retreats are an integral part of the student experience.
44p
nhamnhiqa
01-03-2013
57
1
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Since the discovery of hepatitis C virus (HCV) in 1989, there has been an explosion of research and information on the virus. This is evidenced by the more than 20 000 papers onHCV(as of December, 2000), as well as the numerous reviews in journals and edited books. The purpose of this book is to present an overview of the diVerent disciplines that have contributed to an understanding of the virus, its diseases, current and proposed treatments, and much more.
272p
gian_anh
18-10-2012
49
6
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Therapeutic immunosuppression has very broad applications in clinical medicine, ranging from prevention and treatment of organ and bone marrow transplant rejection, management of various autoimmune disorders (e.g., rheumatoid arthritis), skin diseases, allergies and asthma. Whereas traditionally only a small repertoire of immunosuppressive agents was available for clinical use, recent discoveries have significantly increased the number of approved agents, resulting in numerous trials to further evaluate their potential.
428p
wqwqwqwqwq
23-07-2012
98
7
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