Vascular endothelial

Pulmonary sclerosing (Pneumocytoma) is a rare benign pulmonary tumor of primitive epithelial origin. Because of the unspecific radiological features mimicking malignancies and their histological heterogeneity, the differential diagnosis with adenocarcinoma and carcinoid tumors is still challenging.

6p viling 11-10-2024 2 0   Download

The study's purpose is to in silico molecular docking of some new s-triazine derivatives for anticancer activity on the VEGFR2 receptor. Fifty s-triazine derivatives were screened for anticancer activity through inhibition of VEGFR2 (vascular endothelial growth factor receptor-2) by molecular docking method using AutoDock Vina software.

10p vifilm 11-10-2024 0 0   Download

Bài viết "Nghiên cứu sự thay đổi hàm lượng EGF, VEGF của bệnh nhân có vết thương mạn tính được điều trị bằng huyết tương giàu tiểu cầu" trình bày 2 nội dung: Đánh giá sự thay đổi hàm lượng EGF (epidermal growth factor) và VEGF (vascular endothelial growth factor) trong PRP trước và sau khi hoạt hóa; đánh giá sự thay đổi hàm lượng EGF, VEGF tại chỗ VTMT được điều trị bằng PRP.

11p runthenight01 18-11-2022 14 3   Download

Vascular endothelial growth factor (VEGF) plays a role in the tumor microenvironment. Sorafenib, which inhibits the VEGF pathway, has an immune-modulation function but lacks substantial clinical data. This study aims to explore the efficacy of anti-PD-1 combined sorafenib in advanced hepatocellular carcinoma (HCC).

8p vielonmusk 21-01-2022 18 2   Download

Nghiên cứu nhằm đánh giá khả năng khôi phục giảm phân của tế bào trứng thu từ nang noãn nhỏ và ảnh hưởng của việc bổ sung protein VEGF (Vascular Endothelial Growth Factor) đến sự thành thục nhân tế bào.

5p vichaelisa2711 27-05-2021 27 3   Download

Nghiên cứu nhằm đánh giá ảnh hưởng của yếu tố tăng trưởng nội mao mạch (VEGF: Vascular Endothelial Growth Factor) đến sự thành thục nhân tế bào trứng heo. Phức hợp tế bào trứng (cumulus oocyte complexes–COCs) có từ 2 lớp tế bào cumulus trở lên và đồng đều tế bào chất sẽ được nuôi cấy thành thục trong 44 giờ.

5p vichaelisa2711 27-05-2021 23 2   Download

Tăng huyết áp là một trong những độc tính hay gặp trên bệnh nhân ung thư điều trị với đích nhắm phân tử yếu tố tăng trưởng nội mô mạch máu (VEGF: vascular endothelial growth factor) với xấp xỉ khoảng từ 20% - 30%. Bài viết tổng hợp y văn cơ chế sinh bệnh tăng huyết áp ở góc độ phân tử, cũng như cập nhật các xử trí trong thực hành lâm sàng ở bệnh nhân tăng huyết áp do điều trị ức chế tăng sinh mạch.

4p viankanra2711 15-09-2020 34 2   Download

The long uORF-burdened 5¢UTRs of many genes encoding regulatory proteins involved in cell growth and differentiation contain internal ribosomal entry site (IRES) elements. In a previous study we showed that utilization of the weak IRES of platelet-derived growth factor (PDGF2) is activated during megakaryocytic differentiation.

10p system191 01-06-2013 34 4   Download

The disaccharide galactosea1,3galactose (theaGal epitope) is the major xenoantigen responsible for the hyperacute vascular rejection occurring in pig-to-primates organ trans-plantation. The synthesis of theaGal epitope is catalyzed by the enzyme a1,3-galactosyltransferase (a1,3GalT). To be able to control porcinea1,3GalT gene expression speci®c-ally, we have analyzed the upstreamportionof thea1,3GalT gene, and identi®ed the regulatory sequences.

10p research12 29-04-2013 33 2   Download

Functional cooperationbetween integrins andgrowth factor receptors has been reported for several systems, oneofwhich is the modulation of insulin signaling by avb3 integrin. Plasminogen activator inhibitor type-1 (PAI-1), competes withavb3 integrin for vitronectin (VN) binding. Here we report that PAI-1, in a VN-dependent manner, prevents the cooperation of avb3 integrin with insulin signaling in NIH3T3 fibroblasts, resulting in a decrease in insulin-induced protein kinase B (PKB) phosphorylation, vascular endothelial growth factor (VEGF) expression and cell migration. ...

8p tumor12 20-04-2013 35 3   Download

Sir John Vane named vascular endothelium ‘the maestro of blood circula-tion’. Recently, ‘the maestro’ has become a target for pharmacotherapy of atherothrombotic and diabetic vasculopathies with well known cardio-vascular drugs belonging to the families of Angiotensin Converting Enzyme inhibitors, HMG CoA reductase inhibitors or b1 -Adrenoceptor antagonists. These drugs became upgraded to a position of the pleiotropic endothelial drugs.

12p fptmusic 11-04-2013 39 3   Download

The mechanism by which the CXC chemokine platelet fac-tor 4 (PF-4) inhibits endothelial cell proliferation is unclear. The heparin-binding domains of PF-4 have been reported to prevent vascular endothelial growth factor 165 (VEGF165 ) andfibroblast growth factor 2 (FGF2) frominteractingwith their receptors. However, other studies have suggested that PF-4 acts via heparin-binding independent interactions. Here, we compared the effects of PF-4 on the signalling events involved in the proliferation induced by VEGF165 , which binds heparin, and by VEGF121 , which does not....

0p awards 05-04-2013 37 4   Download

It is now generally accepted that factor XII (FXII) binds to cellular surfaces in the vascular system. One of the suggested receptors of this binding is the glycosylphosphatidylinositol-anchored urokinase-like plasminogen activator (u-PAR) harbored in caveolae/lipid rafts. However, binding of FXII to human umbilical vein endothelial cells (HUVEC) has never been shown to be localized to these specialized mem-brane structures. Using microscopical techniques, we here report that FXII binds to specific patches of the HUVEC plasma membrane with a high density of caveolae....

8p awards 05-04-2013 44 6   Download

Lipid peroxidation and its products such as 4-hydroxy-2-nonenal (HNE) and 4-hydroxyhexenal (HHE) are known to affect redox balance duringagingand various degenerative processes, includingvascular dysfunction. Deterioration of the endothelial cells that line the vascular wall is known to be an underlyingcause of vascular dysfunction. At present, little is known about themechanismbywhichHHE induces endothelial cell death (i.e. apoptosis), although HNE-induced apoptotic cell death has been reported. ...

9p dell39 03-04-2013 25 3   Download

Vascular endothelial growth factor (VEGF) is a key regu-lator of angiogenesis and post-transcriptional regulation plays a major role in VEGF expression. Both the 5¢-and 3¢-UTR are required for VEGF post-transcriptional regu-lation but factors binding to functional sequences within the 5¢-UTR have not been fully characterized. We report here the identification of complexes, binding to theVEGF mRNA 5¢-and3¢-UTR, that contain cold shock domain (CSD) and polypyrimidine tract binding (PTB) RNA binding proteins. ...

13p dell39 03-04-2013 41 5   Download

The macrophage is critical to the innate immune response and contributes to human diseases, including inflammatory arthritis and plaque formation in atherosclerosis. Vascular endothelial growth factor (VEGF) is an angio-genic cytokine that is produced by macrophages.

14p dell39 27-03-2013 39 4   Download

The recruitment of leukocytes from the circulation into tissues requires leu-kocyte migration through the vascular endothelium. The mechanisms by which leukocytes attach and firmly adhere to the endothelial cell surface have been studied in detail. However, much less is known about the last step in this process, the diapedesis of leukocytes through the vascular endo-thelium.

9p inspiron33 25-03-2013 38 4   Download

Leukocytes constantly patrol the vascular system in order to react promptly to infections when and where it is necessary. To fulfil this task, the cells have to enter secondary lymphoid organs and to emigrate into inflamed tissues, which requires them to cross the bar-rier of endothelial cells that line blood vessels.

2p inspiron33 25-03-2013 51 3   Download

Lysophosphatidylcholine induces expression of adhesion molecules; how-ever, the underlying molecular mechanisms of this are not well elucidated. In this study, the intracellular signaling by which lysophosphatidylcholine upregulates vascular cell adhesion molecule-1 and P-selectin was delineated using YPEN-1 and HEK293T cells.

12p galaxyss3 21-03-2013 33 3   Download

Current evidence suggests that the beneficial effects of statins seem to be mediated not only by their lipid-lowering properties but also by improving vascular endothelial cell function. Chronic inhibition of endothelial nitric oxide synthesis by oral administration of Nw-nitro-L-arginine methyl ester (L-NAME) to rats induces early vascular inflammation and subsequent arteriosclerosis.

42p galaxyss3 19-03-2013 42 4   Download