Vascular smooth muscle cells
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Colorectal cancer (CRC) is an aggressive tumor of the gastrointestinal tract, which is a major public health concern worldwide. Despite numerous studies, the precise mechanism of metastasis behind its progression remains elusive.
16p vikoch 27-06-2024 2 1 Download
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To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we create a catalog of genetic variants associated with three stages of transcriptional cis-regulation in primary human coronary artery vascular smooth muscle cells (HCASMCs).
23p viarchimedes 26-01-2022 16 0 Download
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Women account for 60% of all stroke deaths and are more often permanently disabled than men, despite their higher observed stroke incidence. Considering the clinical population affected by stroke, an obvious drawback is that many pre-clinical and clinical studies only investigate young males.
19p vilichoo2711 25-06-2021 16 1 Download
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Vascular disease is a common and often severe complication in diabetes mellitus. Hyperglycemia and hypertension are considered to be two of the leading risk factors for vascular complications in diabetic patients.
15p vimax2711 30-03-2020 17 0 Download
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The inhibitory effect of Isoliquiritigenin on the proliferation of human arterial smooth muscle cell
Isoliquiritigenin (ISL) has various biological activities including as antioxidant and an inhibitor of PI3K/ AKT signaling pathway. However, both oxidative stress and activated PI3K/AKT signaling contribute to the aberrant proliferation of vascular smooth muscle cells (VSMCs).
8p vimax2711 30-03-2020 13 1 Download
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Polyhydroxylsteroids or oxysterols are oxygenated derivatives of steroids and constitute a family of compounds with various biological activities. Especially, oxysterols have been shown to exhibit cytotoxicity in a number of cell lines, including smooth muscle cells, fibroblasts and vascular endothelial cells.
7p abcxyz123_02 03-03-2020 17 1 Download
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Mitofusion-2 (Mfn2) played an important role in regulating vascular smooth muscle cells proliferation, insulin resistance and endoplasmic reticulum stress, which were found to be involved in the development of hypertension. So we inferred that the Mfn2 gene may participate in the pathogenesis of hypertension.
9p viwashington2711 04-12-2019 11 1 Download
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Sepsis, a leading cause of death in intensive care units, is generally associated with vascular dysfunction. However, its pathophysiological process has not been fully clarified, lacking in-depth knowledge of its pathophysiological process may hinder the improvement of diagnosis and therapy for sepsis.
8p vinasaki2711 12-11-2019 13 1 Download
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This study shows that microRNA-320 (miR-320) is associated with many important cell functions, including cell differentiation, proliferation, migration, and apoptosis. However, the role of miR-320 in vascular smooth muscle cells (VSMCs) and proliferative vascular diseases is still completely unclear.
9p vinasaki2711 12-11-2019 16 1 Download
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Morphological, functional, and gene expression studies have established the phenotypic plasticity of smooth muscle cells (SMCs). These cells have been shown to respond to environmental stimulants such as extracellular matrix and growth factors.
12p sony2711 01-02-2019 14 2 Download
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Aortic aneurysm is characterized as localized degeneration of the aorta leading to advanced weakening and widening of the vessel. While the exact mechanisms have yet to be determined, current studies indicate that the degradation of extracellular matrix (ECM) proteins and apoptosis of vascular smooth muscle cells (SMCs) may result in extendibility, dilation, and rupture of the vessel.
15p sony2711 01-02-2019 18 2 Download
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The vascular niche is a site rich in blood vessels, whereas endothelial cells, pericytes, and smooth muscle cells create a microenvironment that recruits mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs), which is important for stem cell mobilization, proliferation, and differentiation. In this study, CD146 + pericytes were purified and enriched from the human umbilical cord vein.
10p nutifooddau 27-01-2019 22 2 Download
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The main component of cerebral amyloid angiopathy (CAA) in Alzheimer’s disease is the amyloid-b protein (Ab), a 4-kDa polypeptide derived from the b-amyloid protein precursor (APP). The accumulation of Ab in the basement membrane has been implicated in the degeneration of adjacent vascular smooth muscle cells (VSMC). However, the mechanism of Ab toxicity is still unclear. In this study, we examined the effect of substrate-bound Ab on VSMC in culture. The use of substrate-bound proteins in cell culture mimics presentation of the proteins to cells as if bound to the basement membrane.
9p system191 01-06-2013 38 3 Download
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The effect of a-tocopheryl hemisuccinate (TS) on lipopolysaccharide (LPS)/interferon-c (IFN)-induced nitric oxide production in rat vascular smooth muscle cells (VSMC) was examined. The LPS/IFN-induced NO production was enhanced by TS but not by the other a-tocopherol (a-T) derivatives a-tocopheryl acetate (TA) and a-tocopheryl nicotinate (TN), or a-T itself. a-T, TA and TN inhibited the enhancement by TS of LPS/IFNinduced NO production.
6p research12 01-06-2013 35 3 Download
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In this study, we have characterized the influence of hypoxia on the expression of hydroxylases crucially involved in col-lagen fiber formation, such as prolyl-4-hydroxylases (Ph4) and procollagen lysyl-hydroxylases (PLOD). Using the rat vascular smooth muscle cell line A7r5, we found that an hypoxic atmosphere caused a characteristic time-dependent five- to 12-fold up-regulation of the mRNAs of the two P4h a-subunits [aI (P4ha1) andaII (P4ha2)] and of two lysyl-hydroxylases (PLOD1 and PLOD2).
8p fptmusic 12-04-2013 27 1 Download
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Although group IIA secretory phospholipase A2 (sPLA2-IIA) is known to be abundantly present in the joints of patients with rheumatoid arthritis (RA), expression of other sPLA2 s in this disease has remained unknown. In this study, we examined the expression and localization of six sPLA2s (groups IIA, IID, IIE, IIF, V and X) in human RA.
18p awards 05-04-2013 38 2 Download
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NO is a gaseous molecule, synthesized by NO synthase (NOS), an enzyme that catalyses the oxidation of L-arginine to NO and L-citrulline. At least two types of NOS can be reported, constitutive NOS (cNOS) and inducible NOS (iNOS) (168) . cNOS is produced by many cells in the upper and lower respiratory system, such as parasympathetic vasodilator nerves, endothelial cells and ciliated mucosa cells (169) .
81p nhacnenzingme 28-03-2013 51 4 Download
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Expression of a previously cloned secretory protein named adrenocortical zonation factor 1 (AZ-1, also called Tin-ag-RP or lipocalin 7) is tightly linked with the zonal differentiation of adrenocortical cells. It is also pre-sent in vascular smooth muscle (VSM), although its function has remained unknown.
17p galaxyss3 21-03-2013 50 2 Download
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In vascular smooth muscle cells and several other cell types, inhibition of Na + ⁄K + -ATPase leads to the expression of early response genes, including c-Fos. We designed this study to examine whether or not a putative Na + i ⁄K + i-sensitive element is located within the c-Fos5¢-UTR from )650 to +103 containing all known response elements activated by ‘classic’ stimuli, such as growth factors and Ca 2+ i-raising compounds.
11p galaxyss3 19-03-2013 34 2 Download
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Osteopontin(OPN) is an arginine-glycine-aspartate (RGD)-contain-ing adhesive glycoprotein that was first identified as a major sialo-protein in bone and subsequently found to be expressed in kidney, brain, macrophages, vascular smooth muscle cells and many cells of epithelial linings. In this study we examined the expression of OPN in MDCK cells in different cellular confluences.
36p galaxyss3 19-03-2013 64 3 Download