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Virus interference
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Geminiviruses cause damaging diseases in several important crop species. However, limited progress has been made in developing crop varieties resistant to these highly diverse DNA viruses. Recently, the bacterial CRISPR/Cas9 system has been transferred to plants to target and confer immunity to geminiviruses.
10p
vigalileogalilei
27-02-2022
11
1
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Canine morbilivirus (canine distemper virus, CDV) is a highly contagious pathogen associated with high morbidity and mortality in susceptible carnivores. Although there are CDV vaccines available, the disease poses a huge threat to dogs and wildlife hosts due to vaccine failures and lack of effective treatment.
17p
vidarwin
23-02-2022
16
1
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CRISPR-Cas systems endow bacterial and archaeal species with adaptive immunity mechanisms to fend off invading phages and foreign genetic elements. CRISPR-Cas9 has been harnessed to confer virus interference against DNA viruses in eukaryotes, including plants.
16p
vielonmusk
30-01-2022
14
0
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CRISPR/Cas systems confer immunity against invading nucleic acids and phages in bacteria and archaea. CRISPR/Cas13a (known previously as C2c2) is a class 2 type VI-A ribonuclease capable of targeting and cleaving single-stranded RNA (ssRNA) molecules of the phage genome.
9p
vialfrednobel
29-01-2022
8
0
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The CRISPR/Cas9 system provides bacteria and archaea with molecular immunity against invading phages and conjugative plasmids. Recently, CRISPR/Cas9 has been used for targeted genome editing in diverse eukaryotic species.
11p
viaristotle
29-01-2022
9
0
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CRISPR/Cas has recently been transferred to plants to make them resistant to geminiviruses, a damaging family of DNA viruses. We discuss the potential and the limitations of this method.
4p
viaristotle
29-01-2022
7
0
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RNA-targeting CRISPR-Cas can provide potential advantages over DNA editing, such as avoiding pleiotropic effects of genome editing, providing precise spatiotemporal regulation, and expanded function including antiviral immunity.
24p
viarchimedes
26-01-2022
8
0
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Bovine viral diarrhea virus (BVDV) is an economically important viral pathogen of domestic and wild ruminants. Apart from cattle, small ruminants (goats and sheep) are also the susceptible hosts for BVDV. BVDV infection could interfere both of the innate and adaptive immunity of the host, while the genes and mechanisms responsible for these effects have not yet been fully understood.
14p
visilicon2711
20-08-2021
6
1
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Viruses have high mutation rates and generally exist as a mixture of variants in biological samples. Next-generation sequencing (NGS) approaches have surpassed Sanger for generating long viral sequences, yet how variants affect NGS de novo assembly remains largely unexplored.
12p
vijeeni2711
24-07-2021
11
0
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Infection of plants by viruses interferes with expression and subcellular localization of plant proteins. Potyviruses comprise the largest and most economically damaging group of plant-infecting RNA viruses.
16p
vijichea2711
28-05-2021
6
1
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White spot syndrome virus (WSSV) is considered as dangerous shrimp pathogen which causes severe economic loss to the shrimp production. Unavailability of protective and therapeutic measures is a serious constraint in aquaculture and till date, there is no effective preventive measure to treat WSSV. In this context, dsRNA was synthesised and used to prevent the replication of WSSV. RNA interference (RNAi) is a promising tool to fight against viral infections.
10p
nguaconbaynhay6
24-06-2020
11
1
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RNA interference (RNAi) is a specific and effective approach for inhibiting viral replication by introducing double-stranded (ds)RNA targeting the viral gene.
7p
viuchiha2711
21-04-2020
14
0
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RNA interference (RNAi) technology has been widely used to knockdown target genes via posttranscriptional silencing. In plants, RNAi is used as an effective tool with diverse applications being developed such as resistance against insects, fungi, viruses, and metabolism manipulation.
12p
vihamax2711
21-04-2020
12
0
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Viral diseases are one of the major factors threatening crop production worldwide. It is estimated that about 15 percent of global crop production is lost due to various plant diseases, and phytopathogenic viruses are thought to cause more than one third of plant diseases. Viruses such as TYLCV, PRSV, CMV, BBTV are some major virus epidemics which cause heavy losses in horticultural crops. Management of plant virus diseases have acquired great importance in the realm of Plant Pathology and call for effective management against them.
14p
chauchaungayxua3
07-02-2020
11
0
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Live virus vaccines are very important parts of the prevention of Infectious Bursal Disease (IBD) in chickens. However, the successful IBD vaccination depends on IBD field pressure, vaccination technique, the immune status of the chicken, and especially IBDV strains used in the vaccines which are able to break through a higher level of maternal-derived antibodies (MDA). The objective of this field study was to compare the efficacy of a new vaccine based on M.B.
9p
sabiendo
02-01-2020
12
0
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African Swine Fever (ASF) is an acute contagious vector borne disease of pigs caused by African Swine Fever virus (ASFV), which is the only known vector transmitted DNA virus and transmitted by the soft tick under genus Ornithodoros. So far the ASF was restricted to most of the African and few European countries. Recently, the disease has crossed the continental borders and reached to Asia and made a huge economic loss in Cambodia, China, Mongolia and Vietnam. It is a peracute disease of domestic and wild pigs in with mortality rate nearly 100%.
4p
nguathienthan2
26-12-2019
8
0
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Chương 3 - Virus học đại cương. Các nội dung chính trong chương này gồm có: Khái niệm, đặc tính của virus, hình thái và kích thước của virus, cấu trúc của virus, nuôi cấy virus, quá trình nhân lên của virus, hiện tượng cản nhiễm (interference),... Mời các bạn cùng tham khảo.
108p
tangtuy12
02-06-2016
182
54
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Preparation and characterisation of attenuated cold-adapted influenza A reassortants derived from the A/Leningrad/134/17/57 donor strain presents the assay was capable of detecting interference where the infectivity ratio for A/Len/17 and A/Beij/32 was 1:7. Progeny viruses were characterised genetically by amplification of defined regions within each of the six internal genes by PCR and identification of the products by restriction enzyme analysis.
9p
thuyancn
01-06-2015
39
4
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1976, Walter Fiers và cộng sự → trình tự hoàn chỉnh một RNA virus 1977, Richard Roberts và Phillip Sharp → alternative splicing 1986, Thomas R. Cech → self-splicing Kary Mullis → kỹ thuật PCR 1989, Thomas R. Cech và Sydney Altman → ribozyme 1990s, các cơ chế RNA antisense và RNA interference
27p
htc_12
13-05-2013
108
31
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The signal transducer and activator of transcription (STAT) family of proteins function to activate gene transcription downstream of myriad cytokine and growth factor signals. The prototype STAT proteins, STAT1 and STAT2, are required for innate and adaptive antimicrobial immune responses that result from interferon signal transduction. While many viruses have evolved the ability to avoid these antiviral cytokines, the Paramyxoviruses are distinct in their abilities to interfere directly with STAT proteins. ...
8p
awards
05-04-2013
38
1
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