Vitamin B12 metabolism

Part 3 book "Marks' basic medical biochemistry - A clinical approach" includes content: Protein digestion and amino acid absorption, fate of amino acid nitrogen - urea cycle; synthesis and degradation of amino acids, tetrahydrofolate, vitamin B12, and sadenosylmethionine; purine and pyrimidine metabolism; intertissue relationships in the metabolism of amino acids,....and other contents.

317p oursky07 24-10-2023 5 3   Download

Vitamin B12 deficiency is a well-known cause of anemia. Pancytopenia and hemolysis are less frequently observed in vitamin B12 deficiency. Reported is the case of a 58-year-old man who presented with dyspnea on exertion, fatigue, and unintentional weight loss.

3p viintuit 26-09-2023 2 0   Download

Measurement of serum cobalamin (vitamin B12) is routinely used in Endocrinology/Metabolism in order to diagnose or rule out a suspected Cobalamin deficiency. Hypervitaminemia B12 or high serum level of cobalamin B12 is a clinical underestimated abnormality.

3p viisac 23-09-2023 4 1   Download

B vitamins and methionine are essential substrates in the one-carbon metabolism pathway involved in DNA synthesis and methylation. They may have essential roles in cancer development. We aimed to evaluate the associations of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer (EC) using data from the Japan Public Health Center-based Prospective Study.

13p vimahuateng 26-11-2021 18 0   Download

Methylmalonic Aciduria and Homocystinemia, cobalamin C (cblC) is an inherited disease of vitamin B12 metabolism with a wide spectrum of clinical manifestations. cblC presenting with pulmonary hypertension (PH) as leading sympotom is rare and easily misdiagnosed because of limited awareness.

4p viorochimaru2711 29-05-2020 5 1   Download

As a very important coenzyme in the cell metabolism, Vitamin B12 (cobalamin, VB12) has been widely used in food and medicine fields. The complete biosynthesis of VB12 requires approximately 30 genes, but overexpression of these genes did not result in expected increase of VB12 production.

11p vihamax2711 21-04-2020 31 0   Download

The metabolic pathways leading froml-[2-13 C]aspartic acid, [2-13 C]glycine andl-[methyl-13 C]methionine to vitamin B12were investigated, focusing on the biosynthetic pathways leading to the aminopropanol moiety of vita-min B12and on the role of the Shemin pathway leading tod-aminolevulinic acid (a biosynthetic intermediate of tetrapyrrole), by means of feeding experiments with Propionibacterium shermaniiin combination with 13 C-NMR spectroscopy.

6p media19 04-03-2013 33 1   Download

The megaloblastic anemias are a group of disorders characterized by the presence of distinctive morphologic appearances of the developing red cells in the bone marrow. The cause is usually deficiency of either cobalamin (vitamin B12) or folate, but megaloblastic anemia may arise because of genetic or acquired abnormalities affecting the metabolism of these vitamins or because of defects in DNA synthesis not related to cobalamin or folate (Table 100-1).

24p socolanong 25-04-2012 62 3   Download

Table 46-3 Causes of Hypokalemia I. Decreased intake A. Starvation B. Clay ingestion II. Redistribution into cells A. Acid-base 1. Metabolic alkalosis B. Hormonal 1. Insulin 2. β2-Adrenergic agonists (endogenous or exogenous) 3. α-Adrenergic antagonists C. Anabolic state 1. Vitamin B12 or folic acid (red blood cell production) 2. Granulocyte-macrophage colony stimulating factor (white blood cell production) 3. Total parenteral nutrition D. Other 1. Pseudohypokalemia 2. Hypothermia 3. Hypokalemic periodic paralysis 4. Barium toxicity III. Increased loss A.

5p ongxaemnumber1 29-11-2010 106 5   Download