Xanthine oxidase inhibitor

Gout is the most prevalent form of arthritis that arises due to hyperuricemia. Xanthine oxidase inhibitors (XOI) are usually prescribed to treat gout. Although treatment options are available, these therapies are associated with side effects, and natural remedies may be proven helpful in this regard. This systematic review aims to present consolidated information on the xanthine oxidase inhibition potential of the plants located in Pakistan.

16p lyhuyenthu 31-01-2023 5 2   Download

Hesperitin, a naturally occurring flavonoid was hybridized with phenolic acids to evaluate its potential to inhibit the activity of xanthine oxidase (XO), a key enzyme which catalyses xanthine to uric acid which is found to be associated with gout and many life style related disorders.

11p vijiraiya2711 27-05-2020 11 1   Download

Lesinurad is an oral inhibitor of urate-anion exchanger transporter 1 and has been approved by the US Food and Drug Administration for combination therapy with a xanthine oxidase inhibitor for the treatment of hyperuricemia associated with refractory gout.

7p vijiraiya2711 27-05-2020 9 0   Download

Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. In this research rutin, a bioactive flavonoid was explored to determine the capability of itself and its derivatives to inhibit xanthine oxidase.

13p vijiraiya2711 27-05-2020 13 1   Download