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Application of a toxin-antibody conjugate to treat acute graft versus host disease in mice models
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In previous studies, we found that doxorubicin-conjugated antiCD137 mAb selectively killed CD137-expressing T cells in vitro. Therefore, in this work we tried to test the ability of this conjugate in vivo. C57lb/6 mice were induced with acute GVHD for further examination.
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