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Báo cáo khoa học: Copper is required for prion protein-associated superoxide dismutase-l activity in Pichia pastoris
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The prion protein (PrP) is the key protein implicated in transmissible spongiform encephalopathies. It is a metalloprotein that binds manganese and copper. The latter is involved in the physiological function of the pro-tein. We have previously found that PrP expression inPichia pastorisaffects intracellular metal ion concentrations and that formation of protease-resistant PrP is induced by additional copper and⁄or manganese.
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