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Báo cáo khoa học: Deciphering the key residues in Plasmodium falciparum b-ketoacyl acyl carrier protein reductase responsible for interactions with Plasmodium falciparum acyl carrier protein

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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The type II fatty acid synthase (FAS) pathway ofPlasmodium falciparumis a validated unique target for developing novel antimalarials, due to its intrinsic differences from the type I pathway operating in humans. b-Ketoacyl acyl carrier protein (ACP) reductase (FabG) performs the NADPH-dependent reduction ofb-ketoacyl-ACP to b-hydroxyacyl-ACP, the first reductive step in the elongation cycle of fatty acid biosynthesis.

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Nội dung Text: Báo cáo khoa học: Deciphering the key residues in Plasmodium falciparum b-ketoacyl acyl carrier protein reductase responsible for interactions with Plasmodium falciparum acyl carrier protein

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