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Báo cáo khóa học: Different associational and conformational behaviors between the second and third repeat fragments in the tau microtubule-binding domain
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The third repeat fragment (R3) in the four-repeat micro-tubule-binding domain of the water-soluble tau protein has been considered to play an essential role in the protein’s filamentous assembly. To clarify the associational and con-formational features that differentiate R3 from the second repeat, R2, the heparin-induced assembly profiles of these peptide fragments were monitored by the thioflavin fluor-escence method and electron microscopy.
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