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Báo cáo khoa học: Dimerization and oligomerization of the chaperone calreticulin

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:9

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The chaperone calreticulin is a highly conserved eukaryotic protein mainly located in the endoplasmic reticulum. It contains a free cysteine SH group but does not form disul-fide-bridged dimers under physiological conditions,indica-ting that the SH group may not be fully accessible in the native protein. Using PAGE,urea gradient gel electro-phoresis,capillary electrophoresis and MS,we show that dimerization through the SH group can be induced by lowering the pH to 5–6,heating,or under conditions that favour partial unfolding such as urea concentrations above 2.6Mor SDS concentrations above 0.025%. ...

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Nội dung Text: Báo cáo khoa học: Dimerization and oligomerization of the chaperone calreticulin

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