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Báo cáo khoa học: Expressed as the sole Hsp90 of yeast, the a and b isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90b generates sensitivity to the Hsp90 inhibitor radicicol

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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Heat shock protein 90 (Hsp90) is a molecular chaperone required for the activity of many of the most important regulatory proteins of eukaryotic cells (the Hsp90 ‘clients’). Vertebrates have two isoforms of cytosolic Hsp90, Hsp90aand Hsp90b. Hsp90bis expressed constitutively to a high level in most tissues and is generally more abundant than Hsp90a, whereas Hsp90a is stress-inducible and overexpressed in many cancerous cells.

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Nội dung Text: Báo cáo khoa học: Expressed as the sole Hsp90 of yeast, the a and b isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90b generates sensitivity to the Hsp90 inhibitor radicicol

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