Báo cáo khoa học: Gram-positive bacterial superantigen outside-in signaling causes toxic shock syndrome
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Staphylococcus aureusand Streptococcus pyogenes(group A streptococci) are Gram-positive pathogens capable of producing a variety of bacterial exo-toxins known as superantigens. Superantigens interact with antigen-present-ing cells (APCs) and T cells to induce T cell proliferation and massive cytokine production, which leads to fever, rash, capillary leak and subse-quent hypotension, the major symptoms of toxic shock syndrome.
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