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Báo cáo khoa học: Human mitochondrial complex I assembly is mediated by NDUFAF1

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

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Complex I (NADH:ubiquinone oxidoreductase) is the largest multiprotein enzyme of the oxidative phosphorylation system. Its assembly in human cells is poorly understood and no proteins assisting this process have yet been described. A good candidate is NDUFAF1, the human homologue of Neurospora crassacomplex I chaperone CIA30. Here, we demonstrate that NDUFAF1 is a mitochondrial protein that is involved in the complex I assembly process.

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Nội dung Text: Báo cáo khoa học: Human mitochondrial complex I assembly is mediated by NDUFAF1

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