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Báo cáo khoa học: In vitro gamma-secretase cleavage of the Alzheimer’s amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:14

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Thec-secretase complex mediates the final proteolytic event in Alzheimer’s disease amyloid-bbiogenesis. This membrane complex of presenilin, ante-rior pharynx defective, nicastrin, and presenilin enhancer-2 cleaves the C-terminal 99-amino acid fragment of the amyloid precursor protein intra-membranously atc-sites to form C-terminally heterogeneous amyloid-b and cleaves at ane-site to release the intracellular domain or e-C-terminal fragment.

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Nội dung Text: Báo cáo khoa học: In vitro gamma-secretase cleavage of the Alzheimer’s amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc

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