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Báo cáo khoa học: Interactions between the amyloid precursor protein C-terminal domain and G proteins mediate calcium dysregulation and amyloid b toxicity in Alzheimer’s disease
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Alzheimer’s disease is characterized by neuropathological accumulations of amyloidb(1–42) [Ab(1–42)], a cleavage product of the amyloid precursor protein (APP). Recent studies have highlighted the role of APP in Ab-med-iated toxicity and have implicated the G-protein system; however, the exact mechanisms underlying this pathway are as yet undetermined.
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