Báo cáo khoa học: Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of b-arrestin 1 recruitment
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The corticotropin releasing factor receptor 1 (CRFR1) belongs to the superfamily of G-protein coupled receptors. Though CRF is involved in the aetiology of several stress-relateddisorders, includingdepressionandanxiety, detailsof CRFR1 regulation such as internalization remain unchar-acterized. In the present study, agonist-induced internal-ization of CRFR1 in HEK293 cells was visualized by confocal microcopy and quantified using the radioligand 125 I-labelled sauvagine.
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