Báo cáo khoa học: LmbE proteins from Bacillus cereus are de-N-acetylases with broad substrate specificity and are highly similar to proteins in Bacillus anthracis

The genomes ofBacillus cereusand its closest relative Bacillus anthracis each contain two LmbE protein family homologs: BC1534 (BA1557) and BC3461 (BA3524). Only a few members of this family have been biochemi-cally characterized including N-acetylglucosaminylphosphatidyl inositol (GlcNAc-PI), 1-d-myo-inosityl-2-acetamido-2-deoxy-a-d-glucopyranoside (GlcNAc-Ins), N,N¢-diacetylchitobiose (GlcNAc2) and lipoglycopeptide antibiotic de-N-acetylases.