Báo cáo khoa học: Lysosomal localization of GLUT8 in the testis – the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction

The class III sugar transport facilitator GLUT8 co-localizes with the lyso-somal protein LAMP1 in heterologous expression systems. GLUT8 carries a [D⁄E]XXXL[L⁄I]-type dileucine sorting signal that has been postulated to retain the protein in an endosomal⁄lysosomal compartment via interactions with clathrin adaptor protein (AP) complexes.