Báo cáo khoa học: Mapping the functional domain of the prion protein
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Prion diseases such as Creutzfeldt–Jakob disease are pos-sibly caused by the conversion of a normal cellular glyco-protein, the prion protein (PrP c ) into an abnormal isoform (PrP Sc ). The process that causes this conversion is unknown, but to understand it requires a detailed insight into the normal activity of PrP c . It has become accepted from results of numerous studies that PrP c is a Cu-binding protein and that its normal function requires Cu.
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