
Báo cáo khoa hoc : Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis
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Mycobacterium tuberculosisis the causative agent of human tuberculosis (TB). Mycobacterial secretory protein ESAT-6 induces matrix metallopro-teinase (MMP)-9 in epithelial cells neighboring infected macrophages. MMP-9 then enhances recruitment of uninfected macrophages, which con-tribute to nascent granuloma maturation and bacterial growth.
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