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Báo cáo khoa học: Molecular basis for specificities of reactivating factors for adenosylcobalamin-dependent diol and glycerol dehydratases

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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Adenosylcobalamin-dependent diol and glycerol dehydratases are isofunc-tional enzymes and undergo mechanism-based inactivation by a physiologi-cal substrate glycerol during catalysis. Inactivated holoenzymes are reactivated by their own reactivating factors that mediate the ATP-depen-dent exchange of an enzyme-bound, damaged cofactor for free adenosylco-balamin through intermediary formation of apoenzyme.

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Nội dung Text: Báo cáo khoa học: Molecular basis for specificities of reactivating factors for adenosylcobalamin-dependent diol and glycerol dehydratases

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