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Báo cáo khoa học: Mutational analysis of the preferential binding of human topoisomerase I to supercoiled DNA
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Human topoisomerase I binds DNA in a topology-dependent fashion with a strong preference for supercoiled DNAs of either sign over relaxed circu-lar DNA. One hypothesis to account for this preference is that a second DNA-binding site exists on the enzyme that mediates an association with the nodes present in supercoiled DNA.
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