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Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:12

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The high-resolution 3D structure of the octapeptide hor-mone angiotensin II (AII) in aqueous solution has been obtained bysimulated annealing calculations, using high-resolutionNMR-derived restraints. After final refinement in explicit water, a familyof 13 structures was obtained with a backbone RMSD of 0.73 ± 0.23 A˚ . AII adopts a fairly compact folded structure, with its C-terminus and N-ter-minus approaching towithin7.2 A ˚ of eachother.

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Nội dung Text: Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131

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