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Báo cáo khoa học: High-resolution NMR studies of the zinc-binding site of the Alzheimer’s amyloid b-peptide

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:14

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Metal binding to the amyloidb-peptide is suggested to be involved in the pathogenesis of Alzheimer’s disease. We used high-resolution NMR to study zinc binding to amyloid b-peptide 1–40 at physiologic pH. Metal binding induces a structural change in the peptide, which is in chemical exchange on an intermediate rate, between the apo-form and the holo-form, with respect to the NMR timescale.

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Nội dung Text: Báo cáo khoa học: High-resolution NMR studies of the zinc-binding site of the Alzheimer’s amyloid b-peptide

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