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Báo cáo khoa học: Solution properties of full-length integrin aIIbb3 refined models suggest environment-dependent induction of alternative bent ⁄extended resting states
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The recently published novel integrinaIIbb3 ectodomain crystallographic structure and NMR structures of its transmembrane⁄cytoplasmic segments were employed to refine previously developed molecular models. Alterna-tive complete aIIbb3 models were built and evaluated, and their shape was compared with EM maps and their computed hydrodynamic⁄conforma-tional properties were compared with the available experimental data.
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