Báo cáo khoa học: No evidence for a role in signal-transduction of Na+/K+-ATPase interaction with putative endogenous ouabain
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A cascade of events (signal-transduction), mainly seen in rat cardiac myocytes and renal cells, is thought to occur after ouabain interaction with a minor fraction of Na + /K + -ATPase. Ahigher intracellularNa + concentration followed sodium pump inhibition by ouabain with a subsequent gradual increase or oscillations in intracellular Ca 2+ con-centration. Whether this increase in intracellular Ca 2+ concentration is part of the cascade, a result of the cascadeor a totally independent phenomenon are conflicting interpre-tations that are discussed. ...
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