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Báo cáo khóa học: Overexpression and enzymatic characterization of Neisseria gonorrhoeae penicillin-binding protein 4

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:10

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The penicillin-binding proteins (PBPs) are ubiquitous bac-terial enzymes involved in cell wall biosynthesis,and are the targets of theb-lactam antibiotics. The low molecular mass Neisseria gonorrhoeaePBP 4 (NG PBP 4) is the fourthPBP revealed in the gonococcal genome. NG PBP 4 was cloned, overexpressed,purified,and characterized for b-lactam binding,DD-carboxypeptidase activity,acyl-donor substrate specificity,transpeptidase activity, inhibitionby a number of active site directed reagents,and pHprofile....

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Nội dung Text: Báo cáo khóa học: Overexpression and enzymatic characterization of Neisseria gonorrhoeae penicillin-binding protein 4

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