Báo cáo khoa học: Physiochemical characterization of the Alzheimer’s disease-related peptides Ab1–42Arctic and Ab1–42wt

The amyloidbpeptide (Ab) is crucial for the pathogenesis of Alzheimer’s disease. Aggregation of monomeric Ab into insoluble amyloid fibrils proceeds through several soluble Abintermediates, including protofibrils, which are believed to be central in the disease process. The main reason for this is their implication in familial Alzheimer’s disease with the Arctic amyloid precursor protein mutation (E693G).