intTypePromotion=1
zunia.vn Tuyển sinh 2024 dành cho Gen-Z zunia.vn zunia.vn
ADSENSE

Báo cáo khoa học: Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:7

35
lượt xem
3
download
 
  Download Vui lòng tải xuống để xem tài liệu đầy đủ

Rubber transferase, acis-prenyltransferase, catalyzes the addition of thousands of isopentenyl diphosphate (IPP) molecules toanallylic diphosphate initiator, suchas farnesyl diphosphate (FPP,1), in the presence of a divalent metal cofactor. In an effort to characterize the catalytic site of rubber transferase, the effects of two types of protein farnesyltransferase inhibitors, several chaetomellic acid A analogs (2,4–7)anda-hydroxyfarnesylphosphonic acid (3), on the ability of rubber transferase to add IPP to the allylic diphosphate initiator were determined. ...

Chủ đề:
Lưu

Nội dung Text: Báo cáo khoa học: Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase

ADSENSE

CÓ THỂ BẠN MUỐN DOWNLOAD

 

Đồng bộ tài khoản
17=>2