Báo cáo khoa học: Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase
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Amino-(3,4-dihydroxyphenyl)methyl phosphonic acid, the phosphonic analogof 3,4-dihydroxyphenylglycine, hadbeen previously reported as a potent inhibitor of tyrosinase. The mechanism of the apparent enzyme inhibition by this com-pound has now been established. Amino-(3,4-dihydroxy-phenyl)methyl phosphonic acid turned out to be a substrate and was oxidized too-quinone, which evolved to a final product identified as 3,4-dihydroxybenzaldehyde, the same as for 3,4-dihydroxyphenylglycine.
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