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Báo cáo khoa học: Regulation of DNp63a by tumor necrosis factor-a in epithelial homeostasis
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A dominant negative form of p63,DNp63a, is critical for maintaining the proliferative potential of epidermal stem cells and progenitor cells. The expression ofDNp63aalso confers a selective advantage for cancer cell survival, underscoring the importance of DNp63a in both normal and neoplastic stratified epithelia.
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