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Báo cáo khoa học: Role of the plasma membrane leaflets in drug uptake and multidrug resistance

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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The present study aimed to investigate the role played by the leaflets of the plasma membrane in the uptake of drugs into cells and in their extrusion by P-glycoprotein and multidrug resistance-associated protein 1. Drug accumulation was monitored by fluorescence resonance energy transfer from trimethylammonium-diphenyl-hexatriene (TMA-DPH) located at the outer leaflet to a rhodamine analog.

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Nội dung Text: Báo cáo khoa học: Role of the plasma membrane leaflets in drug uptake and multidrug resistance

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