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Báo cáo khoa học: Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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We used parameter scanning to emulate changes to the limitingrate for steps inafittedmodel of glucose-derepressed yeast glycolysis. Three flux-control regimes were observed, two of which were under the dominant control of hexose transport, in accordance with various experimental studies andothermodel predictions.Athirdcontrol regime inwhich phosphofructokinase exerted dominant glycolytic flux con-trol was also found, but it appeared to be physiologically unreachable by this model, and all realistically obtainable flux control regimes featured hexose transport as a step involving high flux control....

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Nội dung Text: Báo cáo khoa học: Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis

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