Báo cáo khoa học: Short-chain dehydrogenases/reductases (SDRs) Coenzyme-based functional assignments in completed genomes
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Short-chaindehydrogenases/reductases (SDRs) are enzymes of great functional diversity. Even at sequence identities of typically only 15–30%, specific sequence motifs are detect-able, reflecting common folding patterns. We have devel-oped a functional assignment scheme based on these motifs and we find five families. Two of these families were known previously and are calledclassical andextended families, but they are now distinguished at a further level based on coenzyme specificities.
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