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Báo cáo khoa học: Signaling events mediating activation of brain ethanolamine plasmalogen hydrolysis by ceramide
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Ceramide is a lipid second messenger that acts on mul-tiple-target enzymes, some of which are involved in other signal-transduction systems. We have previously demon-strated that endogenous ceramide modifies the metabolism of brain ethanolamine plasmalogens. The mechanism involved was studied. On the basis of measurements of breakdown products, specific inhibitor effects, and previ-ous findings, we suggest that a plasmalogen-selective phospholipase A2 is the ceramide target.
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